Aging and Microbiome in the Modulation of Vaccine Efficacy
From infancy through to old age, the microbiome plays an important role in modulating the host-immune system. As we age, our immune system and our gut microbiota change significantly in composition and function, which is linked to an increased vulnerability to infectious diseases and a decrease in v...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1545 |
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| author | Manoj Kumar Meenu Mariya James Manoj Kumawat Bilkees Nabi Poonam Sharma Namrata Pal Swasti Shubham Rajnarayan R. Tiwari Devojit Kumar Sarma Ravinder Nagpal |
| author_facet | Manoj Kumar Meenu Mariya James Manoj Kumawat Bilkees Nabi Poonam Sharma Namrata Pal Swasti Shubham Rajnarayan R. Tiwari Devojit Kumar Sarma Ravinder Nagpal |
| author_sort | Manoj Kumar |
| collection | DOAJ |
| description | From infancy through to old age, the microbiome plays an important role in modulating the host-immune system. As we age, our immune system and our gut microbiota change significantly in composition and function, which is linked to an increased vulnerability to infectious diseases and a decrease in vaccine responses. Our microbiome remains largely stable throughout adulthood; however, aging causes a major shift in the composition and function of the gut microbiome, as well as a decrease in diversity. Considering the critical role of the gut microbiome in the host-immune system, it is important to address, prevent, and ameliorate age-related dysbiosis, which could be an effective strategy for preventing/restoring functional deficits in immune responses as we grow older. Several factors, such as the host’s genetics and nutritional state, along with the gut microbiome, can influence vaccine efficacy or reaction. Emerging evidence suggests that the microbiome could be a significant determinant of vaccine immunity. Physiological mechanisms such as senescence, or the steady loss of cellular functions, which affect the aging process and vaccination responses, have yet to be comprehended. Recent studies on several COVID-19 vaccines worldwide have provided a considerable amount of data to support the hypothesis that aging plays a crucial role in modulating COVID-19 vaccination efficacy across different populations. |
| first_indexed | 2024-03-09T10:21:55Z |
| format | Article |
| id | doaj.art-14c8a430b2954fe3b5defe0e6a26a18f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:21:55Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-14c8a430b2954fe3b5defe0e6a26a18f2023-12-01T21:55:46ZengMDPI AGBiomedicines2227-90592022-06-01107154510.3390/biomedicines10071545Aging and Microbiome in the Modulation of Vaccine EfficacyManoj Kumar0Meenu Mariya James1Manoj Kumawat2Bilkees Nabi3Poonam Sharma4Namrata Pal5Swasti Shubham6Rajnarayan R. Tiwari7Devojit Kumar Sarma8Ravinder Nagpal9National Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaDepartment of Biochemistry and Biochemical Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaNational Institute for Research in Environmental Health, Bhopal 462030, IndiaDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32302, USAFrom infancy through to old age, the microbiome plays an important role in modulating the host-immune system. As we age, our immune system and our gut microbiota change significantly in composition and function, which is linked to an increased vulnerability to infectious diseases and a decrease in vaccine responses. Our microbiome remains largely stable throughout adulthood; however, aging causes a major shift in the composition and function of the gut microbiome, as well as a decrease in diversity. Considering the critical role of the gut microbiome in the host-immune system, it is important to address, prevent, and ameliorate age-related dysbiosis, which could be an effective strategy for preventing/restoring functional deficits in immune responses as we grow older. Several factors, such as the host’s genetics and nutritional state, along with the gut microbiome, can influence vaccine efficacy or reaction. Emerging evidence suggests that the microbiome could be a significant determinant of vaccine immunity. Physiological mechanisms such as senescence, or the steady loss of cellular functions, which affect the aging process and vaccination responses, have yet to be comprehended. Recent studies on several COVID-19 vaccines worldwide have provided a considerable amount of data to support the hypothesis that aging plays a crucial role in modulating COVID-19 vaccination efficacy across different populations.https://www.mdpi.com/2227-9059/10/7/1545aginggut microbiomehost-immune systemvaccine responseCOVID-19pandemic |
| spellingShingle | Manoj Kumar Meenu Mariya James Manoj Kumawat Bilkees Nabi Poonam Sharma Namrata Pal Swasti Shubham Rajnarayan R. Tiwari Devojit Kumar Sarma Ravinder Nagpal Aging and Microbiome in the Modulation of Vaccine Efficacy Biomedicines aging gut microbiome host-immune system vaccine response COVID-19 pandemic |
| title | Aging and Microbiome in the Modulation of Vaccine Efficacy |
| title_full | Aging and Microbiome in the Modulation of Vaccine Efficacy |
| title_fullStr | Aging and Microbiome in the Modulation of Vaccine Efficacy |
| title_full_unstemmed | Aging and Microbiome in the Modulation of Vaccine Efficacy |
| title_short | Aging and Microbiome in the Modulation of Vaccine Efficacy |
| title_sort | aging and microbiome in the modulation of vaccine efficacy |
| topic | aging gut microbiome host-immune system vaccine response COVID-19 pandemic |
| url | https://www.mdpi.com/2227-9059/10/7/1545 |
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