Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis
The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant bilia...
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MDPI AG
2023-09-01
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author | Kazuma Kishi Masaki Kuwatani Yuki Ohnishi Yasuhiro Kumaki Hiroyuki Kumeta Hajime Hirata Yunosuke Takishin Ryutaro Furukawa Kosuke Nagai Hiroki Yonemura Shunichiro Nozawa Ryo Sugiura Kazumichi Kawakubo Tomoyasu Aizawa Naoya Sakamoto |
author_facet | Kazuma Kishi Masaki Kuwatani Yuki Ohnishi Yasuhiro Kumaki Hiroyuki Kumeta Hajime Hirata Yunosuke Takishin Ryutaro Furukawa Kosuke Nagai Hiroki Yonemura Shunichiro Nozawa Ryo Sugiura Kazumichi Kawakubo Tomoyasu Aizawa Naoya Sakamoto |
author_sort | Kazuma Kishi |
collection | DOAJ |
description | The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangiography for diagnosis/treatment. The samples metabolomes were analyzed via nuclear magnet resonance spectroscopy using an 800-MHz spectrometer. Metabolomes of malignant and benign diseases were then compared, and multivariate analysis was performed to determine the relevant factors for malignancy/benignancy. For benignancy, no significant predictors were observed. For malignancy, acetone was a significant predictor, with higher concentrations in the malignant group than in the benign group. Regarding the receiver operating characteristic curve analysis for biliary tract carcinoma diagnosis, the predictive value of acetone in duodenal juice was comparable with serum CA19-9 levels (area under the curve: 0.7330 vs. 0.691, <i>p</i> = 0.697). In conclusion, duodenal juice metabolomics is a feasible method that is available for differential diagnosis in the biliary disease field. |
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id | doaj.art-14c9aed1dbe34f5e94c5e33a543a3e4d |
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issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T23:26:26Z |
publishDate | 2023-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-14c9aed1dbe34f5e94c5e33a543a3e4d2023-11-19T07:56:47ZengMDPI AGCancers2072-66942023-09-011517437010.3390/cancers15174370Metabolomics of Duodenal Juice for Biliary Tract Cancer DiagnosisKazuma Kishi0Masaki Kuwatani1Yuki Ohnishi2Yasuhiro Kumaki3Hiroyuki Kumeta4Hajime Hirata5Yunosuke Takishin6Ryutaro Furukawa7Kosuke Nagai8Hiroki Yonemura9Shunichiro Nozawa10Ryo Sugiura11Kazumichi Kawakubo12Tomoyasu Aizawa13Naoya Sakamoto14Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Advanced Transdisciplinary Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, JapanDepartment of Advanced Transdisciplinary Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, JapanDepartment of Advanced Transdisciplinary Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanDepartment of Advanced Transdisciplinary Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, JapanDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Sapporo 060-8648, Hokkaido, JapanThe poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangiography for diagnosis/treatment. The samples metabolomes were analyzed via nuclear magnet resonance spectroscopy using an 800-MHz spectrometer. Metabolomes of malignant and benign diseases were then compared, and multivariate analysis was performed to determine the relevant factors for malignancy/benignancy. For benignancy, no significant predictors were observed. For malignancy, acetone was a significant predictor, with higher concentrations in the malignant group than in the benign group. Regarding the receiver operating characteristic curve analysis for biliary tract carcinoma diagnosis, the predictive value of acetone in duodenal juice was comparable with serum CA19-9 levels (area under the curve: 0.7330 vs. 0.691, <i>p</i> = 0.697). In conclusion, duodenal juice metabolomics is a feasible method that is available for differential diagnosis in the biliary disease field.https://www.mdpi.com/2072-6694/15/17/4370metabolomicsduodenal juicebiliary diseasebiliary tract cancercholangiocarcinoma |
spellingShingle | Kazuma Kishi Masaki Kuwatani Yuki Ohnishi Yasuhiro Kumaki Hiroyuki Kumeta Hajime Hirata Yunosuke Takishin Ryutaro Furukawa Kosuke Nagai Hiroki Yonemura Shunichiro Nozawa Ryo Sugiura Kazumichi Kawakubo Tomoyasu Aizawa Naoya Sakamoto Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis Cancers metabolomics duodenal juice biliary disease biliary tract cancer cholangiocarcinoma |
title | Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis |
title_full | Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis |
title_fullStr | Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis |
title_full_unstemmed | Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis |
title_short | Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis |
title_sort | metabolomics of duodenal juice for biliary tract cancer diagnosis |
topic | metabolomics duodenal juice biliary disease biliary tract cancer cholangiocarcinoma |
url | https://www.mdpi.com/2072-6694/15/17/4370 |
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