Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors.
Downregulation of the T cell system has been proposed as a mechanism to block immunity in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells and their immunological status in newly diagnosed patients. The aim of this study was to characterize the αβ and γδ T ce...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0243545 |
| _version_ | 1819032187261943808 |
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| author | Juan Carlos Andreu-Ballester Lorena Galindo-Regal Julia Hidalgo-Coloma Carmen Cuéllar Carlos García-Ballesteros Carolina Hurtado Natalia Uribe María Del Carmen Martín Ana Isabel Jiménez Francisca López-Chuliá Antonio Llombart-Cussac |
| author_facet | Juan Carlos Andreu-Ballester Lorena Galindo-Regal Julia Hidalgo-Coloma Carmen Cuéllar Carlos García-Ballesteros Carolina Hurtado Natalia Uribe María Del Carmen Martín Ana Isabel Jiménez Francisca López-Chuliá Antonio Llombart-Cussac |
| author_sort | Juan Carlos Andreu-Ballester |
| collection | DOAJ |
| description | Downregulation of the T cell system has been proposed as a mechanism to block immunity in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells and their immunological status in newly diagnosed patients. The aim of this study was to characterize the αβ and γδ T cell subsets in peripheral blood of patients with CC matched with healthy volunteers. In this prospective case-control study, blood samples were obtained from 96 patients with newly diagnosed treatment-naïve infiltrating colonic adenocarcinoma and 48 healthy volunteers. Pathological report at surgery was obtained from all CC patients. A significant decrease in CD3+ γδ T cells and CD3+CD8+ γδ T cells (p<0.001) were observed in CC patients. Apoptosis was significantly increased in all conventional and both αβ and γδ T cell subsets in patients with CC vs healthy subjects. γδ T cells were decreased in peripheral blood of patients with microscopic infiltration in tissues, history of cancer and synchronous colon cancer (p < 0.05). IFN-γ was significantly reduced in CC patients compared to controls. Cytotoxic effector γδ T cells TEMRA (CD8 and CD56) are the proportionally most abundant T cells in peripheral blood of CC patients. Patients with CC present a deep downregulation in the systemic T-cell immunity. These variations are evident through all tumor stages and suggest that a deficiency in γδ T cell populations could be preventing control of tumor progression. This fact prove the role of immunomodulation on CC carcinogenesis. |
| first_indexed | 2024-12-21T06:57:57Z |
| format | Article |
| id | doaj.art-14ca55c1bfe8437ca9723156c10b873e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:57:57Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-14ca55c1bfe8437ca9723156c10b873e2022-12-21T19:12:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024354510.1371/journal.pone.0243545Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors.Juan Carlos Andreu-BallesterLorena Galindo-RegalJulia Hidalgo-ColomaCarmen CuéllarCarlos García-BallesterosCarolina HurtadoNatalia UribeMaría Del Carmen MartínAna Isabel JiménezFrancisca López-ChuliáAntonio Llombart-CussacDownregulation of the T cell system has been proposed as a mechanism to block immunity in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells and their immunological status in newly diagnosed patients. The aim of this study was to characterize the αβ and γδ T cell subsets in peripheral blood of patients with CC matched with healthy volunteers. In this prospective case-control study, blood samples were obtained from 96 patients with newly diagnosed treatment-naïve infiltrating colonic adenocarcinoma and 48 healthy volunteers. Pathological report at surgery was obtained from all CC patients. A significant decrease in CD3+ γδ T cells and CD3+CD8+ γδ T cells (p<0.001) were observed in CC patients. Apoptosis was significantly increased in all conventional and both αβ and γδ T cell subsets in patients with CC vs healthy subjects. γδ T cells were decreased in peripheral blood of patients with microscopic infiltration in tissues, history of cancer and synchronous colon cancer (p < 0.05). IFN-γ was significantly reduced in CC patients compared to controls. Cytotoxic effector γδ T cells TEMRA (CD8 and CD56) are the proportionally most abundant T cells in peripheral blood of CC patients. Patients with CC present a deep downregulation in the systemic T-cell immunity. These variations are evident through all tumor stages and suggest that a deficiency in γδ T cell populations could be preventing control of tumor progression. This fact prove the role of immunomodulation on CC carcinogenesis.https://doi.org/10.1371/journal.pone.0243545 |
| spellingShingle | Juan Carlos Andreu-Ballester Lorena Galindo-Regal Julia Hidalgo-Coloma Carmen Cuéllar Carlos García-Ballesteros Carolina Hurtado Natalia Uribe María Del Carmen Martín Ana Isabel Jiménez Francisca López-Chuliá Antonio Llombart-Cussac Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. PLoS ONE |
| title | Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. |
| title_full | Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. |
| title_fullStr | Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. |
| title_full_unstemmed | Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. |
| title_short | Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors. |
| title_sort | differences in circulating γδ t cells in patients with primary colon cancer and relation with prognostic factors |
| url | https://doi.org/10.1371/journal.pone.0243545 |
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