The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human.

<h4>Background</h4>Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin...

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Bibliographic Details
Main Authors: Isabelle Schepens, Fabienne Jaunin, Nadja Begre, Ursula Läderach, Katrin Marcus, Takashi Hashimoto, Bertrand Favre, Luca Borradori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20805888/pdf/?tool=EBI

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