Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy
Highlights 1. PRP enhances cell viability and osteogenic differentiation of hPDLSCs. 2. Activated PRP dose-dependently increases cell autophagy. 3. Inhibition of autophagy abrogates PRP-induced osteogenic differentiation of hPDLSCs.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-09-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-021-00575-x |
| _version_ | 1818441611294539776 |
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| author | Yunhe Xu Xiaoning Wang Wenshu Liu Weiwei Lu |
| author_facet | Yunhe Xu Xiaoning Wang Wenshu Liu Weiwei Lu |
| author_sort | Yunhe Xu |
| collection | DOAJ |
| description | Highlights 1. PRP enhances cell viability and osteogenic differentiation of hPDLSCs. 2. Activated PRP dose-dependently increases cell autophagy. 3. Inhibition of autophagy abrogates PRP-induced osteogenic differentiation of hPDLSCs. |
| first_indexed | 2024-12-14T18:31:00Z |
| format | Article |
| id | doaj.art-14cb5dfea8c54530b470ad0e84e31491 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-14T18:31:00Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-14cb5dfea8c54530b470ad0e84e314912022-12-21T22:51:47ZengBMCEuropean Journal of Medical Research2047-783X2021-09-0126111010.1186/s40001-021-00575-xThrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagyYunhe Xu0Xiaoning Wang1Wenshu Liu2Weiwei Lu3Department of Stomatology, The First Hospital of Jilin UniversityDepartment of Blood Transfusion, The First Hospital of Jilin UniversityDepartment of Stomatology, The First Hospital of Jilin UniversityDepartment of Blood Transfusion, The First Hospital of Jilin UniversityHighlights 1. PRP enhances cell viability and osteogenic differentiation of hPDLSCs. 2. Activated PRP dose-dependently increases cell autophagy. 3. Inhibition of autophagy abrogates PRP-induced osteogenic differentiation of hPDLSCs.https://doi.org/10.1186/s40001-021-00575-xAutophagyOsteogenic differentiationPeriodontal ligament stem cellsPlatelet-rich plasmaViability |
| spellingShingle | Yunhe Xu Xiaoning Wang Wenshu Liu Weiwei Lu Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy European Journal of Medical Research Autophagy Osteogenic differentiation Periodontal ligament stem cells Platelet-rich plasma Viability |
| title | Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy |
| title_full | Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy |
| title_fullStr | Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy |
| title_full_unstemmed | Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy |
| title_short | Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy |
| title_sort | thrombin activated platelet rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating sirt1 mediated autophagy |
| topic | Autophagy Osteogenic differentiation Periodontal ligament stem cells Platelet-rich plasma Viability |
| url | https://doi.org/10.1186/s40001-021-00575-x |
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