Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection

Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection

Interactions between T follicular helper (Tfh) cells and germinal center B cells are essential for the differentiation of B cells and specific antibody responses against HIV-1 infection. However, the extent to which HIV-1 infection affects the dynamic interplay between these two cell populations in...

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Bibliographic Details
Main Authors: Xiaofan Lu, Xin Zhang, Allen Ka Loon Cheung, Christiane Moog, Huan Xia, Zhen Li, Rui Wang, Yunxia Ji, Wei Xia, Zhiying Liu, Lin Yuan, Xiuwen Wang, Hao Wu, Tong Zhang, Bin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
B cells
T follicular helper cells
ICOS
IL-21
acute HIV-1 infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.837921/full

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