Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome
Monosomy of chromosome X is associated with high prenatal mortality of female embryos and severe developmental abnormalities of patients born with Turner's syndrome (45,XO). The CDMLe012-A-1 human embryonic stem cell (hESC) line, derived from a day six blastocyst with a normal 46,XX female kary...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-08-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506119301382 |
| _version_ | 1818490675817086976 |
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| author | Aleksey Y. Domozhirov John L. Mazzilli Rick A. Wetsel Eva M. Zsigmond |
| author_facet | Aleksey Y. Domozhirov John L. Mazzilli Rick A. Wetsel Eva M. Zsigmond |
| author_sort | Aleksey Y. Domozhirov |
| collection | DOAJ |
| description | Monosomy of chromosome X is associated with high prenatal mortality of female embryos and severe developmental abnormalities of patients born with Turner's syndrome (45,XO). The CDMLe012-A-1 human embryonic stem cell (hESC) line, derived from a day six blastocyst with a normal 46,XX female karyotype spontaneously lost an X-chromosome during cell culture. This 45,XO karyotype was stably maintained for more than 55 passages. Since the CDMLe012-A-1 cells express pluripotent stem cell markers and differentiate into cells derived from the three germ layers, the cell line represents a stable, pluripotent stem cell model of Turner's syndrome. |
| first_indexed | 2024-12-10T17:20:09Z |
| format | Article |
| id | doaj.art-14cc6dc8f13a49f6a2666409538387ee |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-10T17:20:09Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-14cc6dc8f13a49f6a2666409538387ee2022-12-22T01:40:00ZengElsevierStem Cell Research1873-50612019-08-0139Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndromeAleksey Y. Domozhirov0John L. Mazzilli1Rick A. Wetsel2Eva M. Zsigmond3The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, United StatesThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, United StatesThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, United StatesCorresponding author.; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, United StatesMonosomy of chromosome X is associated with high prenatal mortality of female embryos and severe developmental abnormalities of patients born with Turner's syndrome (45,XO). The CDMLe012-A-1 human embryonic stem cell (hESC) line, derived from a day six blastocyst with a normal 46,XX female karyotype spontaneously lost an X-chromosome during cell culture. This 45,XO karyotype was stably maintained for more than 55 passages. Since the CDMLe012-A-1 cells express pluripotent stem cell markers and differentiate into cells derived from the three germ layers, the cell line represents a stable, pluripotent stem cell model of Turner's syndrome.http://www.sciencedirect.com/science/article/pii/S1873506119301382 |
| spellingShingle | Aleksey Y. Domozhirov John L. Mazzilli Rick A. Wetsel Eva M. Zsigmond Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome Stem Cell Research |
| title | Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome |
| title_full | Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome |
| title_fullStr | Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome |
| title_full_unstemmed | Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome |
| title_short | Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome |
| title_sort | generation of cdmle012 a 1 cells a pluripotent human embryonic stem cell model of turner s syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1873506119301382 |
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