Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study
Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in pat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2015-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000300237&lng=en&tlng=en |
| _version_ | 1811256935305969664 |
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| author | Manoel Jacobsen Teixeira Luciana Mendes Bahia Menezes Valquiria Silva Ricardo Galhardoni José Sasson Massako Okada Kleber Paiva Duarte Lin T. Yeng Daniel Ciampi de Andrade |
| author_facet | Manoel Jacobsen Teixeira Luciana Mendes Bahia Menezes Valquiria Silva Ricardo Galhardoni José Sasson Massako Okada Kleber Paiva Duarte Lin T. Yeng Daniel Ciampi de Andrade |
| author_sort | Manoel Jacobsen Teixeira |
| collection | DOAJ |
| description | Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN). Method Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. Results Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant. |
| first_indexed | 2024-04-12T17:48:47Z |
| format | Article |
| id | doaj.art-14cc704982554ffb9125278faa9a426f |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-12T17:48:47Z |
| publishDate | 2015-03-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-14cc704982554ffb9125278faa9a426f2022-12-22T03:22:34ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-03-0173323724010.1590/0004-282X20140232S0004-282X2015000300237Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot studyManoel Jacobsen TeixeiraLuciana Mendes Bahia MenezesValquiria SilvaRicardo GalhardoniJosé SassonMassako OkadaKleber Paiva DuarteLin T. YengDaniel Ciampi de AndradeTopical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN). Method Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. Results Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000300237&lng=en&tlng=encapsaicinadorneuralgia, analgesiaefeitos adversos |
| spellingShingle | Manoel Jacobsen Teixeira Luciana Mendes Bahia Menezes Valquiria Silva Ricardo Galhardoni José Sasson Massako Okada Kleber Paiva Duarte Lin T. Yeng Daniel Ciampi de Andrade Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study Arquivos de Neuro-Psiquiatria capsaicina dor neuralgia, analgesia efeitos adversos |
| title | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
| title_full | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
| title_fullStr | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
| title_full_unstemmed | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
| title_short | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
| title_sort | liposomal topical capsaicin in post herpetic neuralgia a safety pilot study |
| topic | capsaicina dor neuralgia, analgesia efeitos adversos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000300237&lng=en&tlng=en |
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