Influence of metabolic syndrome on cerebral perfusion and cognition
Vascular cognitive impairment (VCI) is associated with chronic cerebral hypoperfusion (CCH) and memory deficits, and often occurs concurrently with metabolic syndrome (MetS). Despite their common occurrence, it is unknown whether CCH and MetS act synergistically to exacerbate VCI-associated patholog...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120300310 |
| _version_ | 1818724919562731520 |
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| author | Jessica M. Livingston Matthew W. McDonald Therese Gagnon Matthew S. Jeffers Mariana Gomez-Smith Sabina Antonescu Greg O. Cron Carlie Boisvert Baptiste Lacoste Dale Corbett |
| author_facet | Jessica M. Livingston Matthew W. McDonald Therese Gagnon Matthew S. Jeffers Mariana Gomez-Smith Sabina Antonescu Greg O. Cron Carlie Boisvert Baptiste Lacoste Dale Corbett |
| author_sort | Jessica M. Livingston |
| collection | DOAJ |
| description | Vascular cognitive impairment (VCI) is associated with chronic cerebral hypoperfusion (CCH) and memory deficits, and often occurs concurrently with metabolic syndrome (MetS). Despite their common occurrence, it is unknown whether CCH and MetS act synergistically to exacerbate VCI-associated pathology. Here, using male Sprague-Dawley rats, we examined the effects of a clinically relevant model of adolescent-onset MetS and adult-onset CCH on neuro-vascular outcomes, combining a cafeteria diet with a 2-vessel occlusion (2VO) model. Using longitudinal imaging, histology, and behavioural assessments, we identified several features of MetS and CCH including reduced cerebral blood volume, white matter atrophy, alterations in hippocampal cell density, and memory impairment. Furthermore, we identified a number of significant associations, potentially predictive of MetS and pathophysiological outcomes. White matter volume was positively correlated to HDL cholesterol; hippocampal cell density was negatively correlated to fasted blood glucose; cerebral blood flow and volume was negatively predicted by the combination of 2VO surgery and increased fasted blood glucose. These results emphasize the importance of including comorbid conditions when modeling VCI, and they outline a highly translational preclinical model that could be used to investigate potential interventions to mitigate VCI-associated pathology and cognitive decline. |
| first_indexed | 2024-12-17T21:34:04Z |
| format | Article |
| id | doaj.art-14cd64a64d29470da6ad6f69bec04ca0 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T21:34:04Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-14cd64a64d29470da6ad6f69bec04ca02022-12-21T21:31:48ZengElsevierNeurobiology of Disease1095-953X2020-04-01137104756Influence of metabolic syndrome on cerebral perfusion and cognitionJessica M. Livingston0Matthew W. McDonald1Therese Gagnon2Matthew S. Jeffers3Mariana Gomez-Smith4Sabina Antonescu5Greg O. Cron6Carlie Boisvert7Baptiste Lacoste8Dale Corbett9Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaOttawa Hospital Research Institute, Neuroscience Program, Ottawa, ON, Canada; Department of Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada; Department of Radiology, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaOttawa Hospital Research Institute, Neuroscience Program, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Neuroscience Program, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Corresponding author at: Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.Vascular cognitive impairment (VCI) is associated with chronic cerebral hypoperfusion (CCH) and memory deficits, and often occurs concurrently with metabolic syndrome (MetS). Despite their common occurrence, it is unknown whether CCH and MetS act synergistically to exacerbate VCI-associated pathology. Here, using male Sprague-Dawley rats, we examined the effects of a clinically relevant model of adolescent-onset MetS and adult-onset CCH on neuro-vascular outcomes, combining a cafeteria diet with a 2-vessel occlusion (2VO) model. Using longitudinal imaging, histology, and behavioural assessments, we identified several features of MetS and CCH including reduced cerebral blood volume, white matter atrophy, alterations in hippocampal cell density, and memory impairment. Furthermore, we identified a number of significant associations, potentially predictive of MetS and pathophysiological outcomes. White matter volume was positively correlated to HDL cholesterol; hippocampal cell density was negatively correlated to fasted blood glucose; cerebral blood flow and volume was negatively predicted by the combination of 2VO surgery and increased fasted blood glucose. These results emphasize the importance of including comorbid conditions when modeling VCI, and they outline a highly translational preclinical model that could be used to investigate potential interventions to mitigate VCI-associated pathology and cognitive decline.http://www.sciencedirect.com/science/article/pii/S0969996120300310Vascular cognitive impairmentCerebral blood flowBlood glucoseHigh-density lipoproteinWhite matter |
| spellingShingle | Jessica M. Livingston Matthew W. McDonald Therese Gagnon Matthew S. Jeffers Mariana Gomez-Smith Sabina Antonescu Greg O. Cron Carlie Boisvert Baptiste Lacoste Dale Corbett Influence of metabolic syndrome on cerebral perfusion and cognition Neurobiology of Disease Vascular cognitive impairment Cerebral blood flow Blood glucose High-density lipoprotein White matter |
| title | Influence of metabolic syndrome on cerebral perfusion and cognition |
| title_full | Influence of metabolic syndrome on cerebral perfusion and cognition |
| title_fullStr | Influence of metabolic syndrome on cerebral perfusion and cognition |
| title_full_unstemmed | Influence of metabolic syndrome on cerebral perfusion and cognition |
| title_short | Influence of metabolic syndrome on cerebral perfusion and cognition |
| title_sort | influence of metabolic syndrome on cerebral perfusion and cognition |
| topic | Vascular cognitive impairment Cerebral blood flow Blood glucose High-density lipoprotein White matter |
| url | http://www.sciencedirect.com/science/article/pii/S0969996120300310 |
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