Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer
Over 3 in 4 adults with diabetes live in low- and middle-income counties and health expenditure also increased 316% over the last 15 years. In this regard, we fabricate low cost, reusable and rapid detection of diabetes sensor based on zinc oxide rod inserted ruthenium-doped carbon nitride (ZnO–g–Ru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/10/1778 |
| _version_ | 1797497197190709248 |
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| author | Habibulla Imran Asrar Alam Venkataraman Dharuman Sooman Lim |
| author_facet | Habibulla Imran Asrar Alam Venkataraman Dharuman Sooman Lim |
| author_sort | Habibulla Imran |
| collection | DOAJ |
| description | Over 3 in 4 adults with diabetes live in low- and middle-income counties and health expenditure also increased 316% over the last 15 years. In this regard, we fabricate low cost, reusable and rapid detection of diabetes sensor based on zinc oxide rod inserted ruthenium-doped carbon nitride (ZnO–g–Ru–C<sub>3</sub>N<sub>4</sub>) modified sensor device. Developed sensor device physically and electrochemically characterized using X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), chronoamperometry (CA) and differential pulse voltammetry (DPV). Sensing device as an effective enzyme-free glucose detection with high sensitivity (346 μA/mM/cm<sup>2</sup>) over the applied lower potential of +0.26 V (vs. Ag/AgCl), fast response (3 s) and broad linear range of (2–28) mM, coupled with a lower limit of detection (3.5 nM). The biosensing device gives better anti-interference ability with justifiable reproducibility, reusability (single electrode re-use 26 times in physiological buffer and 3 times in serum) and stability. Moreover, the real-time applicability of the sensor device was evaluated in human blood, serum and urine samples. |
| first_indexed | 2024-03-10T03:14:59Z |
| format | Article |
| id | doaj.art-14cdb6d977e944899f4d644748af60c7 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:14:59Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-14cdb6d977e944899f4d644748af60c72023-11-23T12:28:08ZengMDPI AGNanomaterials2079-49912022-05-011210177810.3390/nano12101778Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold TransducerHabibulla Imran0Asrar Alam1Venkataraman Dharuman2Sooman Lim3Department of Flexible and Printable Electronics, LANL-JBNU Engineering Institute, Jeonbuk National University, Jeonju 54896, KoreaDepartment of Flexible and Printable Electronics, LANL-JBNU Engineering Institute, Jeonbuk National University, Jeonju 54896, KoreaMolecular Electronics Laboratory, Department of Bioelectronics and Biosensors, Science Campus, Alagappa University, Karaikudi 630004, IndiaDepartment of Flexible and Printable Electronics, LANL-JBNU Engineering Institute, Jeonbuk National University, Jeonju 54896, KoreaOver 3 in 4 adults with diabetes live in low- and middle-income counties and health expenditure also increased 316% over the last 15 years. In this regard, we fabricate low cost, reusable and rapid detection of diabetes sensor based on zinc oxide rod inserted ruthenium-doped carbon nitride (ZnO–g–Ru–C<sub>3</sub>N<sub>4</sub>) modified sensor device. Developed sensor device physically and electrochemically characterized using X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), chronoamperometry (CA) and differential pulse voltammetry (DPV). Sensing device as an effective enzyme-free glucose detection with high sensitivity (346 μA/mM/cm<sup>2</sup>) over the applied lower potential of +0.26 V (vs. Ag/AgCl), fast response (3 s) and broad linear range of (2–28) mM, coupled with a lower limit of detection (3.5 nM). The biosensing device gives better anti-interference ability with justifiable reproducibility, reusability (single electrode re-use 26 times in physiological buffer and 3 times in serum) and stability. Moreover, the real-time applicability of the sensor device was evaluated in human blood, serum and urine samples.https://www.mdpi.com/2079-4991/12/10/1778human bloodlow costenzyme-freeglucoseultra-sensitivediabetes |
| spellingShingle | Habibulla Imran Asrar Alam Venkataraman Dharuman Sooman Lim Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer Nanomaterials human blood low cost enzyme-free glucose ultra-sensitive diabetes |
| title | Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer |
| title_full | Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer |
| title_fullStr | Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer |
| title_full_unstemmed | Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer |
| title_short | Fabrication of Enzyme-Free and Rapid Electrochemical Detection of Glucose Sensor Based on ZnO Rod and Ru Doped Carbon Nitride Modified Gold Transducer |
| title_sort | fabrication of enzyme free and rapid electrochemical detection of glucose sensor based on zno rod and ru doped carbon nitride modified gold transducer |
| topic | human blood low cost enzyme-free glucose ultra-sensitive diabetes |
| url | https://www.mdpi.com/2079-4991/12/10/1778 |
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