Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease
Background: High-flow nasal cannula (HFNC) oxygen therapy provides effective respiratory management in patients with hypoxemic respiratory failure. However, the efficacy and tolerability of HFNC for patients with acute exacerbation of interstitial lung disease (AE-ILD) have not been established. Thi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-02-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753466620906327 |
| _version_ | 1818160771804168192 |
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| author | Takafumi Koyauchi Hideki Yasui Noriyuki Enomoto Hirotsugu Hasegawa Hironao Hozumi Yuzo Suzuki Masato Karayama Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Koshi Yokomura Takafumi Suda |
| author_facet | Takafumi Koyauchi Hideki Yasui Noriyuki Enomoto Hirotsugu Hasegawa Hironao Hozumi Yuzo Suzuki Masato Karayama Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Koshi Yokomura Takafumi Suda |
| author_sort | Takafumi Koyauchi |
| collection | DOAJ |
| description | Background: High-flow nasal cannula (HFNC) oxygen therapy provides effective respiratory management in patients with hypoxemic respiratory failure. However, the efficacy and tolerability of HFNC for patients with acute exacerbation of interstitial lung disease (AE-ILD) have not been established. This study was performed to assess the efficacy and tolerability of HFNC for patients with AE-ILD and identify the early predictors of the outcome of HFNC treatment. Methods: We retrospectively reviewed the records of patients with AE-ILD who underwent HFNC. Overall survival, the success rate of HFNC treatment, adverse events, temporary interruption of treatment, discontinuation of treatment at the patient’s request, and predictors of the outcome of HFNC treatment were evaluated. Results: A total of 66 patients were analyzed. Of these, 26 patients (39.4%) showed improved oxygenation and were successfully withdrawn from HFNC. The 30-day survival rate was 48.5%. No discontinuations at the patient’s request were observed, and no serious adverse events occurred. The pulse oximetric saturation to fraction of inspired oxygen (SpO 2 /FIO 2 ) ratio 24 h after initiating HFNC showed high prediction accuracy (area under the receiver operating characteristic curve, 0.802) for successful HFNC treatment. In the multivariate logistic regression analysis, an SpO 2 /FIO 2 ratio of at least 170.9 at 24 h after initiation was significantly associated with successful HFNC treatment (odds ratio, 51.3; 95% confidence interval, 6.13–430; p < 0.001). Conclusions: HFNC was well tolerated in patients with AE-ILD, suggesting that HFNC is a reasonable respiratory management for these patients. The SpO 2 /FIO 2 ratio 24 h after initiating HFNC was a good predictor of successful HFNC treatment. The reviews of this paper are available via the supplemental material section. |
| first_indexed | 2024-12-11T16:07:11Z |
| format | Article |
| id | doaj.art-14cdbb54299c4b499baa5d76a9bc25f8 |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-12-11T16:07:11Z |
| publishDate | 2020-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-14cdbb54299c4b499baa5d76a9bc25f82022-12-22T00:59:08ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662020-02-011410.1177/1753466620906327Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung diseaseTakafumi KoyauchiHideki YasuiNoriyuki EnomotoHirotsugu HasegawaHironao HozumiYuzo SuzukiMasato KarayamaKazuki FuruhashiTomoyuki FujisawaYutaro NakamuraNaoki InuiKoshi YokomuraTakafumi SudaBackground: High-flow nasal cannula (HFNC) oxygen therapy provides effective respiratory management in patients with hypoxemic respiratory failure. However, the efficacy and tolerability of HFNC for patients with acute exacerbation of interstitial lung disease (AE-ILD) have not been established. This study was performed to assess the efficacy and tolerability of HFNC for patients with AE-ILD and identify the early predictors of the outcome of HFNC treatment. Methods: We retrospectively reviewed the records of patients with AE-ILD who underwent HFNC. Overall survival, the success rate of HFNC treatment, adverse events, temporary interruption of treatment, discontinuation of treatment at the patient’s request, and predictors of the outcome of HFNC treatment were evaluated. Results: A total of 66 patients were analyzed. Of these, 26 patients (39.4%) showed improved oxygenation and were successfully withdrawn from HFNC. The 30-day survival rate was 48.5%. No discontinuations at the patient’s request were observed, and no serious adverse events occurred. The pulse oximetric saturation to fraction of inspired oxygen (SpO 2 /FIO 2 ) ratio 24 h after initiating HFNC showed high prediction accuracy (area under the receiver operating characteristic curve, 0.802) for successful HFNC treatment. In the multivariate logistic regression analysis, an SpO 2 /FIO 2 ratio of at least 170.9 at 24 h after initiation was significantly associated with successful HFNC treatment (odds ratio, 51.3; 95% confidence interval, 6.13–430; p < 0.001). Conclusions: HFNC was well tolerated in patients with AE-ILD, suggesting that HFNC is a reasonable respiratory management for these patients. The SpO 2 /FIO 2 ratio 24 h after initiating HFNC was a good predictor of successful HFNC treatment. The reviews of this paper are available via the supplemental material section.https://doi.org/10.1177/1753466620906327 |
| spellingShingle | Takafumi Koyauchi Hideki Yasui Noriyuki Enomoto Hirotsugu Hasegawa Hironao Hozumi Yuzo Suzuki Masato Karayama Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Koshi Yokomura Takafumi Suda Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease Therapeutic Advances in Respiratory Disease |
| title | Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease |
| title_full | Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease |
| title_fullStr | Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease |
| title_full_unstemmed | Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease |
| title_short | Pulse oximetric saturation to fraction of inspired oxygen (SpO/FIO) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease |
| title_sort | pulse oximetric saturation to fraction of inspired oxygen spo fio ratio 24 hours after high flow nasal cannula hfnc initiation is a good predictor of hfnc therapy in patients with acute exacerbation of interstitial lung disease |
| url | https://doi.org/10.1177/1753466620906327 |
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