| 總結: | Introduction: The infections by S. aureus threaten to turn into a serious problem of
public health. The capacity of the bacteria as colonizing and infected agent in humans
is due to the wide spectrum of factors that it possesses, so much of colonization as of
virulence. Between them, the phenol-soluble modulins (PSMs) have reached a height
because it has been identified that they have lytic activity against leukocytes and erythrocytes,
inflammatory properties and capacity of causing antimicrobial interference
against commensal species and participants in the biofilm formation.
Objective: to describe the advances around the importance of the PSMs in the
pathogenesis of the infections by S. aureus.
Methods: a bibliographic search was carried out in PubMed, including clinical trials,
molecular epidemiology studies and review articles related with the PSMs of S. aureus.
The keywords used were: bacterial toxins, phenol-soluble modulin, Staphylococcus
aureus, Methicillin-Resistant Staphylococcus aureus, Colombia, Cartagena.
Results: a total of 53 articles were included in this review. The PSMs were described
in S. aureus by the first time in 2007, since then, their classification in the bacteria
has been carried out and there has been identified the participation of these molecules
in different biological processes of the bacteria as the quorum sensing, and its
proinflammatory potential. Between the most significant aspects of these molecules is
the possible clinical utility due to the interference inter-specie that has been observed.
Conclusion: there exists increasing information that supports the role of the PSMs in
the pathogenesis of the S. aureus. Nevertheless, the pathogenic power of the bacteria
could be attribute to the sum of several factor dependent of the microorganism and of
the human host. Rev.cienc.biomed. 2014;5(1):107-115
KEYWORDS
Virulence factors, Pathogenicity, Bacterial toxins,Cytotoxins, Staphylococcus aureus
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