Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles
This article presents a model using cellular resonance and rebound properties to model grid cells in medial entorhinal cortex. The model simulates the intrinsic resonance properties of single layer II stellate cells with different frequencies due to the hyperpolarization activated cation current (h...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00201/full |
| _version_ | 1818877973313355776 |
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| author | Michael E Hasselmo Christopher Frank Shay |
| author_facet | Michael E Hasselmo Christopher Frank Shay |
| author_sort | Michael E Hasselmo |
| collection | DOAJ |
| description | This article presents a model using cellular resonance and rebound properties to model grid cells in medial entorhinal cortex. The model simulates the intrinsic resonance properties of single layer II stellate cells with different frequencies due to the hyperpolarization activated cation current (h current). The stellate cells generate rebound spikes after a delay interval that differs for neurons with different resonance frequency. Stellate cells drive inhibitory interneurons to cause rebound from inhibition in an alternating set of stellate cells that drive interneurons to activate the first set of cells. This allows maintenance of activity with cycle skipping of the spiking of cells that matches recent physiological data on theta cycle skipping. The rebound spiking interacts with subthreshold oscillatory input to stellate cells or interneurons regulated by medial septal input and defined relative to the spatial location coded by neurons. The timing of rebound determines whether the network maintains the activity for the same location or shifts to phases of activity representing a different location. Simulations show that spatial firing patterns similar to grid cells can be generated with a range of different resonance frequencies, indicating how grid cells could be generated with low frequencies present in bats and in mice with knockout of the HCN1 subunit of the h current. |
| first_indexed | 2024-12-19T14:06:47Z |
| format | Article |
| id | doaj.art-14cf657d65574e6182a4250748e24d06 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-19T14:06:47Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-14cf657d65574e6182a4250748e24d062022-12-21T20:18:17ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372014-10-01810.3389/fnsys.2014.0020150273Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading anglesMichael E Hasselmo0Christopher Frank Shay1Boston UniversityBoston UniversityThis article presents a model using cellular resonance and rebound properties to model grid cells in medial entorhinal cortex. The model simulates the intrinsic resonance properties of single layer II stellate cells with different frequencies due to the hyperpolarization activated cation current (h current). The stellate cells generate rebound spikes after a delay interval that differs for neurons with different resonance frequency. Stellate cells drive inhibitory interneurons to cause rebound from inhibition in an alternating set of stellate cells that drive interneurons to activate the first set of cells. This allows maintenance of activity with cycle skipping of the spiking of cells that matches recent physiological data on theta cycle skipping. The rebound spiking interacts with subthreshold oscillatory input to stellate cells or interneurons regulated by medial septal input and defined relative to the spatial location coded by neurons. The timing of rebound determines whether the network maintains the activity for the same location or shifts to phases of activity representing a different location. Simulations show that spatial firing patterns similar to grid cells can be generated with a range of different resonance frequencies, indicating how grid cells could be generated with low frequencies present in bats and in mice with knockout of the HCN1 subunit of the h current.http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00201/fullEntorhinal Cortexoscillatory interferencespatial navigationstellate cellswhole-cell patch recording |
| spellingShingle | Michael E Hasselmo Christopher Frank Shay Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles Frontiers in Systems Neuroscience Entorhinal Cortex oscillatory interference spatial navigation stellate cells whole-cell patch recording |
| title | Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| title_full | Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| title_fullStr | Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| title_full_unstemmed | Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| title_short | Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| title_sort | grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse travelling waves with multiple heading angles |
| topic | Entorhinal Cortex oscillatory interference spatial navigation stellate cells whole-cell patch recording |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00201/full |
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