DNA repair and cytokines: TGF-beta, IL-6, and thrombopoietin as different biomarkers of radioresistance

DNA repair and cytokines: TGF-beta, IL-6, and thrombopoietin as different biomarkers of radioresistance

Double strand breaks (DSBs) induced by radiotherapy are highly cytotoxic lesions, leading to chromosomal aberrations and cell death. ATM-dependent DNA-damage response, non-homologous end joining, and homologous recombination pathways coordinately contribute to repairing DSBs in higher eukaryotes. It...

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Bibliographic Details
Main Authors:	Francesca Bianca Aiello, Lucia Centurione
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-07-01
Series:	Frontiers in Oncology
Subjects:	Cytokines DNA Repair Cancer radioresistance ATM-dependent DNA damage response
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00175/full

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