Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure
Abstract To date, little is known about the usefulness of ultra-high frequency ultrasound (UHF-US, 50–70 MHz) in clinical practice for the diagnosis of dysimmune neuropathies. We present a prospective study aimed at comparing UHF-US alterations of nerves and fascicles in chronic inflammatory demyeli...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54452-8 |
| _version_ | 1797274912913620992 |
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| author | Angela Puma Nicolae Grecu Raluca Ș. Badea Adeline Morisot Roxana Zugravu Mihai B. Ioncea Michele Cavalli Oana Lăcătuș Andra Ezaru Chorfa Hacina Luisa Villa Charles Raffaelli Nicolas Azulay Sabrina Sacconi |
| author_facet | Angela Puma Nicolae Grecu Raluca Ș. Badea Adeline Morisot Roxana Zugravu Mihai B. Ioncea Michele Cavalli Oana Lăcătuș Andra Ezaru Chorfa Hacina Luisa Villa Charles Raffaelli Nicolas Azulay Sabrina Sacconi |
| author_sort | Angela Puma |
| collection | DOAJ |
| description | Abstract To date, little is known about the usefulness of ultra-high frequency ultrasound (UHF-US, 50–70 MHz) in clinical practice for the diagnosis of dysimmune neuropathies. We present a prospective study aimed at comparing UHF-US alterations of nerves and fascicles in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), distal CIDP (d-CIDP) and anti-MAG neuropathy and their relationships with clinical and electrodiagnostic (EDX) features. 28 patients were included (twelve CIDP, 6 d-CIDP and 10 anti-MAG) and ten healthy controls. Each patient underwent neurological examination, EDX and UHF-US study of median and ulnar nerves bilaterally. UHF-US was reliable in differentiating immune neuropathies from controls when using mean and/or segmental nerve and/or fascicle cross-sectional area (CSA); furthermore, fascicle ratio (fascicle/nerve CSA) was a reliable factor for differentiating d-CIDP from other types of polyneuropathies. The fascicle CSA appears to be more increased in CIDP and its variant than in anti-MAG neuropathy. UHF-US offers information beyond simple nerve CSA and allows for a better characterization of the different forms of dysimmune neuropathies. |
| first_indexed | 2024-03-07T15:04:58Z |
| format | Article |
| id | doaj.art-14d23869b6c5464db9538beec8614e2a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:58Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-14d23869b6c5464db9538beec8614e2a2024-03-05T18:54:42ZengNature PortfolioScientific Reports2045-23222024-02-0114111110.1038/s41598-024-54452-8Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structureAngela Puma0Nicolae Grecu1Raluca Ș. Badea2Adeline Morisot3Roxana Zugravu4Mihai B. Ioncea5Michele Cavalli6Oana Lăcătuș7Andra Ezaru8Chorfa Hacina9Luisa Villa10Charles Raffaelli11Nicolas Azulay12Sabrina Sacconi13Peripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NiceNeurology Department, University Emergency Hospital BucharestNeurology Department, University Emergency Hospital BucharestDepartment of Public Health, University Hospital of NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NiceUltrasound Department, Université Côte d’Azur, CHU NiceUltrasound Department, Université Côte d’Azur, CHU NicePeripheral Nervous System and Muscle Department, Université Côte d’Azur, CHU NiceAbstract To date, little is known about the usefulness of ultra-high frequency ultrasound (UHF-US, 50–70 MHz) in clinical practice for the diagnosis of dysimmune neuropathies. We present a prospective study aimed at comparing UHF-US alterations of nerves and fascicles in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), distal CIDP (d-CIDP) and anti-MAG neuropathy and their relationships with clinical and electrodiagnostic (EDX) features. 28 patients were included (twelve CIDP, 6 d-CIDP and 10 anti-MAG) and ten healthy controls. Each patient underwent neurological examination, EDX and UHF-US study of median and ulnar nerves bilaterally. UHF-US was reliable in differentiating immune neuropathies from controls when using mean and/or segmental nerve and/or fascicle cross-sectional area (CSA); furthermore, fascicle ratio (fascicle/nerve CSA) was a reliable factor for differentiating d-CIDP from other types of polyneuropathies. The fascicle CSA appears to be more increased in CIDP and its variant than in anti-MAG neuropathy. UHF-US offers information beyond simple nerve CSA and allows for a better characterization of the different forms of dysimmune neuropathies.https://doi.org/10.1038/s41598-024-54452-8 |
| spellingShingle | Angela Puma Nicolae Grecu Raluca Ș. Badea Adeline Morisot Roxana Zugravu Mihai B. Ioncea Michele Cavalli Oana Lăcătuș Andra Ezaru Chorfa Hacina Luisa Villa Charles Raffaelli Nicolas Azulay Sabrina Sacconi Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure Scientific Reports |
| title | Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure |
| title_full | Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure |
| title_fullStr | Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure |
| title_full_unstemmed | Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure |
| title_short | Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure |
| title_sort | typical cidp distal variant cidp and anti mag antibody neuropathy an ultra high frequency ultrasound comparison of nerve structure |
| url | https://doi.org/10.1038/s41598-024-54452-8 |
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