Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

Abstract Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival. Herein, we investigated the cell death mechanism activated in glutamine-addicted tumor cells in response to the limitation of glutami...

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Bibliographic Details
Main Authors: Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas, Carmen Palacios
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05346-y

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