Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field
Magnetic fields are safe and used in noninvasive physical therapies. Numerous studies have confirmed that magnetic fields have good osteogenic effects and certain value for clinical application in accelerating orthodontic tooth movement, promoting bone-implant integration, promoting fracture healing...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2024-04-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2024.04.009 |
| _version_ | 1797263644081258496 |
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| author | CHEN Jinquan LIU Yuyan WANG Guoqing SUN Xiumei |
| author_facet | CHEN Jinquan LIU Yuyan WANG Guoqing SUN Xiumei |
| author_sort | CHEN Jinquan |
| collection | DOAJ |
| description | Magnetic fields are safe and used in noninvasive physical therapies. Numerous studies have confirmed that magnetic fields have good osteogenic effects and certain value for clinical application in accelerating orthodontic tooth movement, promoting bone-implant integration, promoting fracture healing and improving the effects of distraction osteogenesis. Magnetic fields are expected to become applied as effective auxiliary methods for treating oral diseases. To support the clinical application of magnetic fields, this article reviews the applications of magnetic fields in the oral cavity, the biological effects on bone cells and the molecular mechanisms through which magnetic fields regulate bone metabolism. The biological effects of magnetic fields on bone cells include promoting osteogenesis by osteoblasts and mesenchymal stem cells and inhibiting bone resorption by osteoclasts. At the molecular level, bone cells sense and respond to magnetic stimulation, and through various mechanisms, such as displacement currents, Lorentz forces, and free radical pair effects, stimuli are transformed into biologically recognizable electrical signals that activate complex downstream signaling pathways, such as the P2 purinergic receptor signaling pathway, adenosine receptor signaling pathway, transforming growth factor-β receptor signaling pathway, mammalian target of rapamycin (mTOR) pathway, and Notch pathway. In addition, magnetic parameters, which are the factors affecting the osteogenic effects of magnetic fields, are discussed. However, the mechanisms of the osteogenic effects of magnetic fields are unclear, and further studies of these mechanisms could provide effective strategies for bone regeneration and periodontal tissue regeneration. In addition, considering the target of magnetic field therapies, combination with other drugs could lead to new strategies for the treatment of oral diseases. |
| first_indexed | 2024-04-25T00:16:17Z |
| format | Article |
| id | doaj.art-14d3faa1b255499ba11d936a197179fd |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-25T00:16:17Z |
| publishDate | 2024-04-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-14d3faa1b255499ba11d936a197179fd2024-03-13T02:20:19ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562024-04-0132430230910.12016/j.issn.2096⁃1456.2024.04.009Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral fieldCHEN Jinquan0LIU Yuyan1WANG Guoqing2SUN Xiumei3Department of Orthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Orthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Orthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Orthodontics, Hospital of Stomatology, Jilin UniversityMagnetic fields are safe and used in noninvasive physical therapies. Numerous studies have confirmed that magnetic fields have good osteogenic effects and certain value for clinical application in accelerating orthodontic tooth movement, promoting bone-implant integration, promoting fracture healing and improving the effects of distraction osteogenesis. Magnetic fields are expected to become applied as effective auxiliary methods for treating oral diseases. To support the clinical application of magnetic fields, this article reviews the applications of magnetic fields in the oral cavity, the biological effects on bone cells and the molecular mechanisms through which magnetic fields regulate bone metabolism. The biological effects of magnetic fields on bone cells include promoting osteogenesis by osteoblasts and mesenchymal stem cells and inhibiting bone resorption by osteoclasts. At the molecular level, bone cells sense and respond to magnetic stimulation, and through various mechanisms, such as displacement currents, Lorentz forces, and free radical pair effects, stimuli are transformed into biologically recognizable electrical signals that activate complex downstream signaling pathways, such as the P2 purinergic receptor signaling pathway, adenosine receptor signaling pathway, transforming growth factor-β receptor signaling pathway, mammalian target of rapamycin (mTOR) pathway, and Notch pathway. In addition, magnetic parameters, which are the factors affecting the osteogenic effects of magnetic fields, are discussed. However, the mechanisms of the osteogenic effects of magnetic fields are unclear, and further studies of these mechanisms could provide effective strategies for bone regeneration and periodontal tissue regeneration. In addition, considering the target of magnetic field therapies, combination with other drugs could lead to new strategies for the treatment of oral diseases.https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2024.04.009magnetic fields，jaw，osteogenesis，bone resorption，signal transduction，osseointegration，fracture healing，tooth movement techniques，bone lengthening， |
| spellingShingle | CHEN Jinquan LIU Yuyan WANG Guoqing SUN Xiumei Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field 口腔疾病防治 magnetic fields， jaw， osteogenesis， bone resorption， signal transduction， osseointegration， fracture healing， tooth movement techniques， bone lengthening， |
| title | Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| title_full | Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| title_fullStr | Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| title_full_unstemmed | Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| title_short | Research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| title_sort | research progress on applications and mechanisms of osteogenesis effect of magnetic fields in oral field |
| topic | magnetic fields， jaw， osteogenesis， bone resorption， signal transduction， osseointegration， fracture healing， tooth movement techniques， bone lengthening， |
| url | https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2024.04.009 |
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