Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors
Plant polyphenols have received considerable attention in recent years due to their ability to undergo oxidation-triggered self-polymerization, forming biocompatible versatile coatings and templated nanoparticles (NPs) that can be leveraged for a variety of biomedical applications. Here we show for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/21/3815 |
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| author | Suhair Sunoqrot Eveen Al-Shalabi Lina Hasan Ibrahim Hiba Zalloum |
| author_facet | Suhair Sunoqrot Eveen Al-Shalabi Lina Hasan Ibrahim Hiba Zalloum |
| author_sort | Suhair Sunoqrot |
| collection | DOAJ |
| description | Plant polyphenols have received considerable attention in recent years due to their ability to undergo oxidation-triggered self-polymerization, forming biocompatible versatile coatings and templated nanoparticles (NPs) that can be leveraged for a variety of biomedical applications. Here we show for the first time that untemplated NPs can be conveniently synthesized from the abundant plant polyphenol quercetin (QCT) simply by incubation with an oxidizing agent in a universal organic solvent, followed by self-assembly upon gradual addition of water. The process yielded NPs of around 180−200 nm in size with a range of colors that resembled light to medium-brown skin tones. The NPs were characterized by UV-Vis, FT-IR, and <sup>1</sup>H-NMR spectroscopy and by dynamic light scattering and transmission electron microscopy to understand their physicochemical properties. Antioxidant and cell viability assays were also conducted to demonstrate the NPs’ free-radical scavenging activity and biocompatibility, altogether providing valuable insights into the structure and function of this emerging class of nanomaterials to guide future biomedical applications. |
| first_indexed | 2024-12-13T09:00:03Z |
| format | Article |
| id | doaj.art-14d47040ab5246ada4698068cb83bd1f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T09:00:03Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-14d47040ab5246ada4698068cb83bd1f2022-12-21T23:53:11ZengMDPI AGMolecules1420-30492019-10-012421381510.3390/molecules24213815molecules24213815Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching ColorsSuhair Sunoqrot0Eveen Al-Shalabi1Lina Hasan Ibrahim2Hiba Zalloum3Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, JordanHamdi Mango Center for Scientific Research, University of Jordan, Amman 11942, JordanPlant polyphenols have received considerable attention in recent years due to their ability to undergo oxidation-triggered self-polymerization, forming biocompatible versatile coatings and templated nanoparticles (NPs) that can be leveraged for a variety of biomedical applications. Here we show for the first time that untemplated NPs can be conveniently synthesized from the abundant plant polyphenol quercetin (QCT) simply by incubation with an oxidizing agent in a universal organic solvent, followed by self-assembly upon gradual addition of water. The process yielded NPs of around 180−200 nm in size with a range of colors that resembled light to medium-brown skin tones. The NPs were characterized by UV-Vis, FT-IR, and <sup>1</sup>H-NMR spectroscopy and by dynamic light scattering and transmission electron microscopy to understand their physicochemical properties. Antioxidant and cell viability assays were also conducted to demonstrate the NPs’ free-radical scavenging activity and biocompatibility, altogether providing valuable insights into the structure and function of this emerging class of nanomaterials to guide future biomedical applications.https://www.mdpi.com/1420-3049/24/21/3815quercetinantioxidant nanoparticlesoxidative self-polymerizationsize controlgreen chemistry |
| spellingShingle | Suhair Sunoqrot Eveen Al-Shalabi Lina Hasan Ibrahim Hiba Zalloum Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors Molecules quercetin antioxidant nanoparticles oxidative self-polymerization size control green chemistry |
| title | Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors |
| title_full | Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors |
| title_fullStr | Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors |
| title_full_unstemmed | Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors |
| title_short | Nature-Inspired Polymerization of Quercetin to Produce Antioxidant Nanoparticles with Controlled Size and Skin Tone-Matching Colors |
| title_sort | nature inspired polymerization of quercetin to produce antioxidant nanoparticles with controlled size and skin tone matching colors |
| topic | quercetin antioxidant nanoparticles oxidative self-polymerization size control green chemistry |
| url | https://www.mdpi.com/1420-3049/24/21/3815 |
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