THE EFFECT OF GREEN TEA LEAF EXTRACT ON SPATIAL MEMORY FUNCTION AND SUPEROXYDE DISMUTASE ENZYME ACTIVITY IN MICE WITH D-GALACTOSE INDUCED DIMENTIA
Background: Oxidative stress and inflammation play an important role in pathogenesis of brain aging and neurodegenerative diseases such as Alzheimer. Green tea has been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotective activity. Objectives: to determine the effect of gree...
| المؤلفون الرئيسيون: | , , |
|---|---|
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Universitas Sultan Agung Semarang
2017-04-01
|
| سلاسل: | Sains Medika |
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1050 |
| الملخص: | Background: Oxidative stress and inflammation play an important role in pathogenesis of brain aging and neurodegenerative diseases such as Alzheimer. Green tea has been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotective activity. Objectives: to determine the effect of green tea extract on spatial memory function and superoxide dismutase enzyme activity in mice with D-galactose induced dementia
Methods: An experimental study using "post test only control group design". Twenty male BALB/c Mice aged 6-8 weeks were divided into 4 groups. Negative control group (NG) was induced by subcutaneous injection of D-galactose (150 mg/kg BW) once daily for 6 weeks. GT-90, GT-270, GT-540 were induced by D-galactose and orally administered with 90, 270, and 540 mg/kg BW of green tea extract once daily for 6 weeks. The spatial memory functions were assessed using Morris water maze and SOD enzyme activities were evaluated using ELISA. One-way Anova and Kruskal-Wallis were used for statistical analysis.
Results: mean percentage of latency time in the GT-90 (35.29 (SD= 2.69)%), GT-270 (35.28 (SD= 2.62)%), and GT-540 (35.62 (SD=5.05)%) were significantly higher compared to that of NG (20.38 (SD = 3.21)%), p <0.05). SOD enzyme activity in the GT-270 (0.78 (SD = 0.07) U/ml) was significantly higher compared to that of NG (0.51 (SD = 0.01) U ml), p= 0.004).
Conclusion: Green tea extract may improve spatial memory function and the activity of superoxide dismutase enzyme in mice with D-galactose induced dementia. |
|---|---|
| تدمد: | 2085-1545 2339-093X |