Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells
The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises independent of cell-cycle progression and Notch activ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11349 |
| _version_ | 1818839182710145024 |
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| author | Mayumi Okamoto Takaki Miyata Daijiro Konno Hiroki R. Ueda Takeya Kasukawa Mitsuhiro Hashimoto Fumio Matsuzaki Ayano Kawaguchi |
| author_facet | Mayumi Okamoto Takaki Miyata Daijiro Konno Hiroki R. Ueda Takeya Kasukawa Mitsuhiro Hashimoto Fumio Matsuzaki Ayano Kawaguchi |
| author_sort | Mayumi Okamoto |
| collection | DOAJ |
| description | The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises independent of cell-cycle progression and Notch activation. |
| first_indexed | 2024-12-19T03:50:14Z |
| format | Article |
| id | doaj.art-14d86c76d9cd4db3ae8082859d9eaad4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:50:14Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-14d86c76d9cd4db3ae8082859d9eaad42022-12-21T20:37:01ZengNature PortfolioNature Communications2041-17232016-04-017111610.1038/ncomms11349Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cellsMayumi Okamoto0Takaki Miyata1Daijiro Konno2Hiroki R. Ueda3Takeya Kasukawa4Mitsuhiro Hashimoto5Fumio Matsuzaki6Ayano Kawaguchi7Department of Anatomy and Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Cell Biology, Nagoya University Graduate School of MedicineLaboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN Kobe InstituteLaboratory for Systems Biology, Center for Developmental Biology, RIKEN Kobe InstituteFunctional Genomics Unit, Center for Developmental Biology, RIKEN Kobe InstituteDepartment of Anatomy and Cell Biology, Nagoya University Graduate School of MedicineLaboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN Kobe InstituteDepartment of Anatomy and Cell Biology, Nagoya University Graduate School of MedicineThe molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises independent of cell-cycle progression and Notch activation.https://doi.org/10.1038/ncomms11349 |
| spellingShingle | Mayumi Okamoto Takaki Miyata Daijiro Konno Hiroki R. Ueda Takeya Kasukawa Mitsuhiro Hashimoto Fumio Matsuzaki Ayano Kawaguchi Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells Nature Communications |
| title | Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells |
| title_full | Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells |
| title_fullStr | Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells |
| title_full_unstemmed | Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells |
| title_short | Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells |
| title_sort | cell cycle independent transitions in temporal identity of mammalian neural progenitor cells |
| url | https://doi.org/10.1038/ncomms11349 |
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