Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling
Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using a <i>Drosophila...
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MDPI AG
2022-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/426 |
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| author | Tian Wei Lei Wu Xiaowen Ji Yan Gao Guiran Xiao |
| author_facet | Tian Wei Lei Wu Xiaowen Ji Yan Gao Guiran Xiao |
| author_sort | Tian Wei |
| collection | DOAJ |
| description | Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using a <i>Drosophila</i> UC model induced by sodium dodecyl sulfate (SDS), we investigated the defensive effect of UA on intestinal damage. The results showed that UA could significantly protect <i>Drosophila</i> from the damage caused by SDS exposure. Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT). Moreover, the proliferation and differentiation of intestine stem cells (ISCs) as well as the excessive activation of the c-Jun N-terminal kinase (JNK)-dependent JAK/STAT signaling pathway induced by SDS were restored by UA. In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway. UA may provide a theoretical basis for functional food or natural medicine development. |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:43:13Z |
| publishDate | 2022-02-01 |
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| series | Antioxidants |
| spelling | doaj.art-14dc48dc3a8649e4881f0f034abb4ce62023-11-23T18:33:39ZengMDPI AGAntioxidants2076-39212022-02-0111242610.3390/antiox11020426Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK SignalingTian Wei0Lei Wu1Xiaowen Ji2Yan Gao3Guiran Xiao4Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaUrsolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using a <i>Drosophila</i> UC model induced by sodium dodecyl sulfate (SDS), we investigated the defensive effect of UA on intestinal damage. The results showed that UA could significantly protect <i>Drosophila</i> from the damage caused by SDS exposure. Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT). Moreover, the proliferation and differentiation of intestine stem cells (ISCs) as well as the excessive activation of the c-Jun N-terminal kinase (JNK)-dependent JAK/STAT signaling pathway induced by SDS were restored by UA. In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway. UA may provide a theoretical basis for functional food or natural medicine development.https://www.mdpi.com/2076-3921/11/2/426ursolic acidulcerative colitisJNKJAK/STAT<i>Drosophila</i> |
| spellingShingle | Tian Wei Lei Wu Xiaowen Ji Yan Gao Guiran Xiao Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling Antioxidants ursolic acid ulcerative colitis JNK JAK/STAT <i>Drosophila</i> |
| title | Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling |
| title_full | Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling |
| title_fullStr | Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling |
| title_full_unstemmed | Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling |
| title_short | Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced <i>Drosophila</i> Ulcerative Colitis Model by Inhibiting the JNK Signaling |
| title_sort | ursolic acid protects sodium dodecyl sulfate induced i drosophila i ulcerative colitis model by inhibiting the jnk signaling |
| topic | ursolic acid ulcerative colitis JNK JAK/STAT <i>Drosophila</i> |
| url | https://www.mdpi.com/2076-3921/11/2/426 |
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