Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats
Background: Avipattikar churna, a poly-herbal formulation, is one of the popular ayurvedic formulations which is used for peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking. Aims: This study was carried out to evaluate the anti-secretor...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3058/38%20-%205309_E(C)_PF1(M)_F(H)_PF1(PP)_PFA(PUH)_PF1(HR)_NEW.pdf |
| Summary: | Background: Avipattikar churna, a poly-herbal formulation, is
one of the popular ayurvedic formulations which is used for
peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking.
Aims: This study was carried out to evaluate the anti-secretory
and the anti-ulcerogenic activities of the churna and to compare its activity with that of ranitidine in a pyloric ligated model
of rats.
Material and methods: Four groups of rats with 6 animals in
each served as the ulcer controls, churna low dose (500 mg/
kg), churna high dose (750mg/kg) and ranitidine (25mg/kg). The
control group rats received only vehicle (2% (v/v) gum acacia),
while the rats of the other groups received the respective dose
of the churna or ranitidine which was suspended in the vehicle.
The treatments were given twice a day, orally, for two days.
After 1 hour of the last dose, pyloric ligations were performed
and the rats were sacrificed for evaluation after four hours of
the ligations. The gastric contents were collected and its volume, pH and acidity were measured. The numbers of ulcers
and their lengths were measured which were used to calculate
the gastric irritancy index and the curative ratio. The histological examinations of the gastric tissues were also performed.
Results: The churna, in both doses, significantly decreased the
volumes of the gastric contents, the ulcer score, the length of
the ulcer, the gastric irritancy index and pH increased as compared to those in the control group. The effects of the churna
were comparable to that of ranitidine. The histopathological
evaluation of the gastric tissue also supported the results.
Conclusion: Avipattikar churna has anti-secretory and antiulcerogenic effects which are comparable to those of ranitidine
in peptic ulcer diseases. |
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| ISSN: | 2249-782X 0973-709X |