Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats
Background: Avipattikar churna, a poly-herbal formulation, is one of the popular ayurvedic formulations which is used for peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking. Aims: This study was carried out to evaluate the anti-secretor...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2013-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3058/38%20-%205309_E(C)_PF1(M)_F(H)_PF1(PP)_PFA(PUH)_PF1(HR)_NEW.pdf |
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| author | Sudesh Gyawali Gulam Muhammad Khan Shreekrishna Lamichane Jaya Gautam Saurav Ghimire Rashmi Adhikari Reshma Lamsal |
| author_facet | Sudesh Gyawali Gulam Muhammad Khan Shreekrishna Lamichane Jaya Gautam Saurav Ghimire Rashmi Adhikari Reshma Lamsal |
| author_sort | Sudesh Gyawali |
| collection | DOAJ |
| description | Background: Avipattikar churna, a poly-herbal formulation, is
one of the popular ayurvedic formulations which is used for
peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking.
Aims: This study was carried out to evaluate the anti-secretory
and the anti-ulcerogenic activities of the churna and to compare its activity with that of ranitidine in a pyloric ligated model
of rats.
Material and methods: Four groups of rats with 6 animals in
each served as the ulcer controls, churna low dose (500 mg/
kg), churna high dose (750mg/kg) and ranitidine (25mg/kg). The
control group rats received only vehicle (2% (v/v) gum acacia),
while the rats of the other groups received the respective dose
of the churna or ranitidine which was suspended in the vehicle.
The treatments were given twice a day, orally, for two days.
After 1 hour of the last dose, pyloric ligations were performed
and the rats were sacrificed for evaluation after four hours of
the ligations. The gastric contents were collected and its volume, pH and acidity were measured. The numbers of ulcers
and their lengths were measured which were used to calculate
the gastric irritancy index and the curative ratio. The histological examinations of the gastric tissues were also performed.
Results: The churna, in both doses, significantly decreased the
volumes of the gastric contents, the ulcer score, the length of
the ulcer, the gastric irritancy index and pH increased as compared to those in the control group. The effects of the churna
were comparable to that of ranitidine. The histopathological
evaluation of the gastric tissue also supported the results.
Conclusion: Avipattikar churna has anti-secretory and antiulcerogenic effects which are comparable to those of ranitidine
in peptic ulcer diseases. |
| first_indexed | 2024-12-12T14:53:00Z |
| format | Article |
| id | doaj.art-14dd2be821a8438caba280f8dee79e17 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T14:53:00Z |
| publishDate | 2013-06-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-14dd2be821a8438caba280f8dee79e172022-12-22T00:20:58ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-06-01761135113910.7860/JCDR/2013/5309.3058Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental RatsSudesh Gyawali0Gulam Muhammad Khan1Shreekrishna Lamichane2Jaya Gautam3Saurav Ghimire4Rashmi Adhikari5Reshma Lamsal6Assistant Professor, Department of Pharmacology, Manipal College of Medical Sciences (MCOMS), Deepheight, Pokhara, Nepal.Associate Professor, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Student, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Student, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Student, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Student, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Student, Department of Pharmacy, School of Health & Allied Sciences, Pokhara University, Nepal.Background: Avipattikar churna, a poly-herbal formulation, is one of the popular ayurvedic formulations which is used for peptic ulcer diseases but the scientific documentation with regards to its effect for the indication is lacking. Aims: This study was carried out to evaluate the anti-secretory and the anti-ulcerogenic activities of the churna and to compare its activity with that of ranitidine in a pyloric ligated model of rats. Material and methods: Four groups of rats with 6 animals in each served as the ulcer controls, churna low dose (500 mg/ kg), churna high dose (750mg/kg) and ranitidine (25mg/kg). The control group rats received only vehicle (2% (v/v) gum acacia), while the rats of the other groups received the respective dose of the churna or ranitidine which was suspended in the vehicle. The treatments were given twice a day, orally, for two days. After 1 hour of the last dose, pyloric ligations were performed and the rats were sacrificed for evaluation after four hours of the ligations. The gastric contents were collected and its volume, pH and acidity were measured. The numbers of ulcers and their lengths were measured which were used to calculate the gastric irritancy index and the curative ratio. The histological examinations of the gastric tissues were also performed. Results: The churna, in both doses, significantly decreased the volumes of the gastric contents, the ulcer score, the length of the ulcer, the gastric irritancy index and pH increased as compared to those in the control group. The effects of the churna were comparable to that of ranitidine. The histopathological evaluation of the gastric tissue also supported the results. Conclusion: Avipattikar churna has anti-secretory and antiulcerogenic effects which are comparable to those of ranitidine in peptic ulcer diseases.https://jcdr.net/articles/PDF/3058/38%20-%205309_E(C)_PF1(M)_F(H)_PF1(PP)_PFA(PUH)_PF1(HR)_NEW.pdfavipattikar churnagastric acidpeptic ulcerpyloric ligationranitidinerats |
| spellingShingle | Sudesh Gyawali Gulam Muhammad Khan Shreekrishna Lamichane Jaya Gautam Saurav Ghimire Rashmi Adhikari Reshma Lamsal Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats Journal of Clinical and Diagnostic Research avipattikar churna gastric acid peptic ulcer pyloric ligation ranitidine rats |
| title | Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats |
| title_full | Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats |
| title_fullStr | Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats |
| title_full_unstemmed | Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats |
| title_short | Evaluation of Anti-Secretory and Anti-Ulcerogenic Activities of Avipattikar Churna on The Peptic Ulcers in Experimental Rats |
| title_sort | evaluation of anti secretory and anti ulcerogenic activities of avipattikar churna on the peptic ulcers in experimental rats |
| topic | avipattikar churna gastric acid peptic ulcer pyloric ligation ranitidine rats |
| url | https://jcdr.net/articles/PDF/3058/38%20-%205309_E(C)_PF1(M)_F(H)_PF1(PP)_PFA(PUH)_PF1(HR)_NEW.pdf |
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