Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich’s Ataxia: A New Synthetic Route

Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich’s Ataxia: A New Synthetic Route

Friedreich’s ataxia (FRDA) is caused by transcriptional repression of the nuclear FXN gene encoding the essential mitochondrial protein frataxin. Based on the hypothesis that the acetylation state of the histone proteins is responsible for gene silencing in FRDA, previous work in our lab identified...

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Bibliographic Details
Main Authors: Joel M. Gottesfeld, James R. Rusche, Elisabetta Soragni, Vincent Jacques, Chunping Xu
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Pharmaceuticals
Subjects:
HDAC inhibitor
Friedreich’s ataxia
click chemistry
Online Access:http://www.mdpi.com/1424-8247/4/12/1578/

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