Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer
With a greater understanding of tumor biology, novel molecular-targeted strategies that block cancer progression pathways have been evaluated as a new therapeutic approach for treating non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such a...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2012-02-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.02.08 |
| _version_ | 1828498431013814272 |
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| author | Yuan LI Lihua SONG |
| author_facet | Yuan LI Lihua SONG |
| author_sort | Yuan LI |
| collection | DOAJ |
| description | With a greater understanding of tumor biology, novel molecular-targeted strategies that block cancer progression pathways have been evaluated as a new therapeutic approach for treating non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, show favorable response to EGFR mutant lung cancer in some populations of NSCLC patients. However, the efficacy of EGFR-TKIs is limited by either primary (de novo) or acquired resistance after therapy. This review will focus on recently identified mechanisms of primary and acquired resistance to EGFR TKIs and strategies currently being employed to overcome resistance. |
| first_indexed | 2024-12-11T13:06:59Z |
| format | Article |
| id | doaj.art-14df28e169c8478490a2aa5a403e7fe4 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-11T13:06:59Z |
| publishDate | 2012-02-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-14df28e169c8478490a2aa5a403e7fe42022-12-22T01:06:17ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872012-02-0115210611110.3779/j.issn.1009-3419.2012.02.08Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung CancerYuan LILihua SONGWith a greater understanding of tumor biology, novel molecular-targeted strategies that block cancer progression pathways have been evaluated as a new therapeutic approach for treating non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, show favorable response to EGFR mutant lung cancer in some populations of NSCLC patients. However, the efficacy of EGFR-TKIs is limited by either primary (de novo) or acquired resistance after therapy. This review will focus on recently identified mechanisms of primary and acquired resistance to EGFR TKIs and strategies currently being employed to overcome resistance.http://dx.doi.org/10.3779/j.issn.1009-3419.2012.02.08Epidermal growth factor receptor-tyrosine kinase inhibitorsLung neoplasmsDrug resistanceMechanism |
| spellingShingle | Yuan LI Lihua SONG Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Epidermal growth factor receptor-tyrosine kinase inhibitors Lung neoplasms Drug resistance Mechanism |
| title | Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer |
| title_full | Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer |
| title_fullStr | Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer |
| title_full_unstemmed | Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer |
| title_short | Research Progress on Resistance Mechanisms of Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer |
| title_sort | research progress on resistance mechanisms of epidermal growth factor receptor
tyrosine kinase inhibitors in non small cell lung cancer |
| topic | Epidermal growth factor receptor-tyrosine kinase inhibitors Lung neoplasms Drug resistance Mechanism |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.02.08 |
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