Cell and context-dependent sorting of neuropathy-associated protein NDRG1 – insights from canine tissues and primary Schwann cell cultures

Cell and context-dependent sorting of neuropathy-associated protein NDRG1 – insights from canine tissues and primary Schwann cell cultures

Abstract Background Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth disease type 4D, and it is assumed that analogous canine diseases can be use...

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Bibliographic Details
Main Authors: Fredrik S. Skedsmo, Michael A. Tranulis, Arild Espenes, Kristian Prydz, Kaspar Matiasek, Gjermund Gunnes, Lene C. Hermansen, Karin H. Jäderlund
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Veterinary Research
Subjects:
Polyneuropathy
Charcot-Marie-tooth disease (CMT)
Dog
Greyhound
Alaskan malamute
Microtubules
Online Access:http://link.springer.com/article/10.1186/s12917-019-1872-2

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