Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types
Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from huma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7423 |
| _version_ | 1797502160075751424 |
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| author | Tomasz Staniowski Anna Zawadzka-Knefel Katarzyna Skośkiewicz-Malinowska |
| author_facet | Tomasz Staniowski Anna Zawadzka-Knefel Katarzyna Skośkiewicz-Malinowska |
| author_sort | Tomasz Staniowski |
| collection | DOAJ |
| description | Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from human teeth is due to their easy availability and a non-invasive procedure of collecting the material. Three key components are required for tissue regeneration: stem cells, appropriate scaffold material and growth factors. Depending on the source of the new tissue or organ, there are several types of transplants. In this review, the following division into four transplant types is applied due to genetic differences between the donor and the recipient: xenotransplantation, allotransplantation, autotransplantation and isotransplantation (however, due to the lack of research, type was not included). In vivo studies have shown that Dental Pulp Stem Cells (DPSCs)can form a dentin-pulp complex, nerves, adipose, bone, cartilage, skin, blood vessels and myocardium, which gives hope for their use in various biomedical areas, such as immunotherapy and regenerative therapy. This review presents the current in vivo research and advances to provide new biological insights and therapeutic possibilities of using DPSCs. |
| first_indexed | 2024-03-10T03:28:57Z |
| format | Article |
| id | doaj.art-14e0ed7e23c749b9bbc85cef10dd2b09 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:28:57Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-14e0ed7e23c749b9bbc85cef10dd2b092023-11-23T09:43:49ZengMDPI AGMolecules1420-30492021-12-012624742310.3390/molecules26247423Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant TypesTomasz Staniowski0Anna Zawadzka-Knefel1Katarzyna Skośkiewicz-Malinowska2Department of Conservative Dentistry with Endodontics, Wroclaw Medical University, 50-425 Wrocław, PolandDepartment of Conservative Dentistry with Endodontics, Wroclaw Medical University, 50-425 Wrocław, PolandDepartment of Conservative Dentistry with Endodontics, Wroclaw Medical University, 50-425 Wrocław, PolandStem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from human teeth is due to their easy availability and a non-invasive procedure of collecting the material. Three key components are required for tissue regeneration: stem cells, appropriate scaffold material and growth factors. Depending on the source of the new tissue or organ, there are several types of transplants. In this review, the following division into four transplant types is applied due to genetic differences between the donor and the recipient: xenotransplantation, allotransplantation, autotransplantation and isotransplantation (however, due to the lack of research, type was not included). In vivo studies have shown that Dental Pulp Stem Cells (DPSCs)can form a dentin-pulp complex, nerves, adipose, bone, cartilage, skin, blood vessels and myocardium, which gives hope for their use in various biomedical areas, such as immunotherapy and regenerative therapy. This review presents the current in vivo research and advances to provide new biological insights and therapeutic possibilities of using DPSCs.https://www.mdpi.com/1420-3049/26/24/7423endodonticsdental pulp stem cellsscaffoldgrowth factor |
| spellingShingle | Tomasz Staniowski Anna Zawadzka-Knefel Katarzyna Skośkiewicz-Malinowska Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types Molecules endodontics dental pulp stem cells scaffold growth factor |
| title | Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types |
| title_full | Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types |
| title_fullStr | Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types |
| title_full_unstemmed | Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types |
| title_short | Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types |
| title_sort | therapeutic potential of dental pulp stem cells according to different transplant types |
| topic | endodontics dental pulp stem cells scaffold growth factor |
| url | https://www.mdpi.com/1420-3049/26/24/7423 |
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