Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma
Aim: The incidence of thyroid cancer has increased dramatically in recent decades. Multifocality is considered a poor prognostic factor for papillary thyroid carcinoma (PTC). Patients with multifocal PTC (MPTC) are at high risk for local recurrence, as well as lymphatic and distal metastases. This s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Duzce University
2023-04-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/2762662 |
| _version_ | 1797419898773700608 |
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| author | Zahra Shilan Seyed Ziaeddin Rasihashemi Samad Farashi Bonab Ebrahim Farashi |
| author_facet | Zahra Shilan Seyed Ziaeddin Rasihashemi Samad Farashi Bonab Ebrahim Farashi |
| author_sort | Zahra Shilan |
| collection | DOAJ |
| description | Aim: The incidence of thyroid cancer has increased dramatically in recent decades. Multifocality is considered a poor prognostic factor for papillary thyroid carcinoma (PTC). Patients with multifocal PTC (MPTC) are at high risk for local recurrence, as well as lymphatic and distal metastases. This study examined the features and outcomes of MPTC.
Material and Methods: This retrospective study was conducted on 300 patients with PTC. Patients were classified into a multifocal group and a unifocal group. The pathological features of the PTC and the patients’ outcomes were analyzed and compared.
Results: The multifocal group included 146 patients (48.7%), while the unifocal group included 154 patients (51.3%). The occurrence of multifocality was higher in females than in males (Odds ratio, OR: 2.37, 95% confidence interval, CI: 1.20-4.67, p=0.015). Tumor size of >1 cm in the multifocal group was larger than in the unifocal group (2.5 and 2.2 cm, respectively, p=0.021). Moreover, in multifocal group higher moderate risk of recurrence was detected than in the unifocal group (OR: 1.63, 95% CI: 1.01-2.60, p=0.044). At follow-up after treatment, MPTC patients had higher lymph node metastasis (OR: 2.89, 95% CI: 1.23-6.80, p=0.014). In addition, significantly higher thyroglobulin plasma levels (p=0.026) and disease recurrence (OR: 2.41, 95% CI: 1.05-5.52, p=0.037) were found in the multifocal group compared to the unifocal group.
Conclusion: Patients with MPTC had a higher risk of disease recurrence, and multifocality was concluded to be an independent prognostic factor for overall disease recurrence. |
| first_indexed | 2024-03-09T06:54:50Z |
| format | Article |
| id | doaj.art-14e1528b15654d8191e2cea8af1f7d70 |
| institution | Directory Open Access Journal |
| issn | 1307-671X |
| language | English |
| last_indexed | 2024-03-09T06:54:50Z |
| publishDate | 2023-04-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj.art-14e1528b15654d8191e2cea8af1f7d702023-12-03T10:05:18ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2023-04-01251505510.18678/dtfd.120214397Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid CarcinomaZahra Shilan0Seyed Ziaeddin Rasihashemi1Samad Farashi Bonab2Ebrahim Farashi3Faculty of Medicine, Tabriz Azad University of Medical Sciences, Tabriz, IranDepartment of Cardiothoracic Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Cardiothoracic Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranAim: The incidence of thyroid cancer has increased dramatically in recent decades. Multifocality is considered a poor prognostic factor for papillary thyroid carcinoma (PTC). Patients with multifocal PTC (MPTC) are at high risk for local recurrence, as well as lymphatic and distal metastases. This study examined the features and outcomes of MPTC. Material and Methods: This retrospective study was conducted on 300 patients with PTC. Patients were classified into a multifocal group and a unifocal group. The pathological features of the PTC and the patients’ outcomes were analyzed and compared. Results: The multifocal group included 146 patients (48.7%), while the unifocal group included 154 patients (51.3%). The occurrence of multifocality was higher in females than in males (Odds ratio, OR: 2.37, 95% confidence interval, CI: 1.20-4.67, p=0.015). Tumor size of >1 cm in the multifocal group was larger than in the unifocal group (2.5 and 2.2 cm, respectively, p=0.021). Moreover, in multifocal group higher moderate risk of recurrence was detected than in the unifocal group (OR: 1.63, 95% CI: 1.01-2.60, p=0.044). At follow-up after treatment, MPTC patients had higher lymph node metastasis (OR: 2.89, 95% CI: 1.23-6.80, p=0.014). In addition, significantly higher thyroglobulin plasma levels (p=0.026) and disease recurrence (OR: 2.41, 95% CI: 1.05-5.52, p=0.037) were found in the multifocal group compared to the unifocal group. Conclusion: Patients with MPTC had a higher risk of disease recurrence, and multifocality was concluded to be an independent prognostic factor for overall disease recurrence.https://dergipark.org.tr/en/download/article-file/2762662papiller tiroid karsinomu,tiroidektomimultifokalite,nükspapillary thyroid carcinomathyroidectomymultifocalityrecurrence |
| spellingShingle | Zahra Shilan Seyed Ziaeddin Rasihashemi Samad Farashi Bonab Ebrahim Farashi Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma Düzce Tıp Fakültesi Dergisi papiller tiroid karsinomu, tiroidektomi multifokalite, nüks papillary thyroid carcinoma thyroidectomy multifocality recurrence |
| title | Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma |
| title_full | Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma |
| title_fullStr | Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma |
| title_full_unstemmed | Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma |
| title_short | Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma |
| title_sort | outcomes and pathological features of total thyroidectomy in patients with multifocal papillary thyroid carcinoma |
| topic | papiller tiroid karsinomu, tiroidektomi multifokalite, nüks papillary thyroid carcinoma thyroidectomy multifocality recurrence |
| url | https://dergipark.org.tr/en/download/article-file/2762662 |
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