SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recent...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.793523/full |
| _version_ | 1818433072025042944 |
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| author | Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh |
| author_facet | Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh |
| author_sort | Yogita Chhichholiya |
| collection | DOAJ |
| description | miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recently, geneticists across the world started reporting single nucleotide polymorphism (SNPs) in seed sequences of miRNAs. Similarly, SNPs are also reported in various target sequences of these miRNAs. Both the scenarios lead to dysregulated gene expression which may result in the progression of diseases. In the present paper, we explore SNPs in various miRNAs and their target sequences reported in various human cancers as well as diabetes. Similarly, we also present evidence of these mutations in various other human diseases. |
| first_indexed | 2024-12-14T16:15:16Z |
| format | Article |
| id | doaj.art-14e17280fec144778a366805258f952e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-14T16:15:16Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-14e17280fec144778a366805258f952e2022-12-21T22:54:54ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-12-011210.3389/fgene.2021.793523793523SNPs in miRNAs and Target Sequences: Role in Cancer and DiabetesYogita ChhichholiyaAman Kumar SuryanPrabhat SumanAnjana MunshiSandeep SinghmiRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recently, geneticists across the world started reporting single nucleotide polymorphism (SNPs) in seed sequences of miRNAs. Similarly, SNPs are also reported in various target sequences of these miRNAs. Both the scenarios lead to dysregulated gene expression which may result in the progression of diseases. In the present paper, we explore SNPs in various miRNAs and their target sequences reported in various human cancers as well as diabetes. Similarly, we also present evidence of these mutations in various other human diseases.https://www.frontiersin.org/articles/10.3389/fgene.2021.793523/fullmiRNAmicroRNAtarget genesseed sequencesSNPscancer |
| spellingShingle | Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes Frontiers in Genetics miRNA microRNA target genes seed sequences SNPs cancer |
| title | SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes |
| title_full | SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes |
| title_fullStr | SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes |
| title_full_unstemmed | SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes |
| title_short | SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes |
| title_sort | snps in mirnas and target sequences role in cancer and diabetes |
| topic | miRNA microRNA target genes seed sequences SNPs cancer |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.793523/full |
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