Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review
Ewing’s sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/10/1849 |
| _version_ | 1797626735034892288 |
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| author | Mubashir Hassan Saba Shahzadi Amal Malik Salah ud Din Muhammad Yasir Wanjoo Chun Andrzej Kloczkowski |
| author_facet | Mubashir Hassan Saba Shahzadi Amal Malik Salah ud Din Muhammad Yasir Wanjoo Chun Andrzej Kloczkowski |
| author_sort | Mubashir Hassan |
| collection | DOAJ |
| description | Ewing’s sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and prognostic biomarkers in various cancers. Furthermore, microRNAs have shown to be a good therapeutic agent due to their involvement in the dysregulation of various molecular pathways linked to tumour progression, invasion, angiogenesis, and metastasis. In this review, comprehensive data mining was employed to explore various microRNAs that might have therapeutic potential as target molecules in the treatment of ES. |
| first_indexed | 2024-03-11T10:14:25Z |
| format | Article |
| id | doaj.art-14e1a9d4cf144cff8dba17ec3a906277 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T10:14:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-14e1a9d4cf144cff8dba17ec3a9062772023-11-16T10:29:32ZengMDPI AGGenes2073-44252023-09-011410184910.3390/genes14101849Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite ReviewMubashir Hassan0Saba Shahzadi1Amal Malik2Salah ud Din3Muhammad Yasir4Wanjoo Chun5Andrzej Kloczkowski6The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAInstitute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54590, PakistanDepartment of Bioinformatics, University of Okara, Okara 56130, PakistanDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of KoreaDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of KoreaThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAEwing’s sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and prognostic biomarkers in various cancers. Furthermore, microRNAs have shown to be a good therapeutic agent due to their involvement in the dysregulation of various molecular pathways linked to tumour progression, invasion, angiogenesis, and metastasis. In this review, comprehensive data mining was employed to explore various microRNAs that might have therapeutic potential as target molecules in the treatment of ES.https://www.mdpi.com/2073-4425/14/10/1849Ewing’s sarcomamiRNAEWSR1therapeutic targets |
| spellingShingle | Mubashir Hassan Saba Shahzadi Amal Malik Salah ud Din Muhammad Yasir Wanjoo Chun Andrzej Kloczkowski Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review Genes Ewing’s sarcoma miRNA EWSR1 therapeutic targets |
| title | Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review |
| title_full | Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review |
| title_fullStr | Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review |
| title_full_unstemmed | Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review |
| title_short | Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review |
| title_sort | oncomeric profiles of micrornas as new therapeutic targets for treatment of ewing s sarcoma a composite review |
| topic | Ewing’s sarcoma miRNA EWSR1 therapeutic targets |
| url | https://www.mdpi.com/2073-4425/14/10/1849 |
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