Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma
Abstract Background The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features wer...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-09-01
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| Series: | Journal of the Egyptian National Cancer Institute |
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| Online Access: | http://link.springer.com/article/10.1186/s43046-020-00047-z |
| _version_ | 1818515052111593472 |
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| author | Nabiha Missaoui Ahlem Bdioui Atika Baccouche Oussema Belkacem Wissem Hmida Moncef Mokni Sihem Hmissa |
| author_facet | Nabiha Missaoui Ahlem Bdioui Atika Baccouche Oussema Belkacem Wissem Hmida Moncef Mokni Sihem Hmissa |
| author_sort | Nabiha Missaoui |
| collection | DOAJ |
| description | Abstract Background The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section. Results Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (p = 0.001), positive surgical margin (p = 0.005), and shorter recurrence-free survival (RFS; Log Rank test, p = 0.026). Ki-67 and p27 expression was associated with stage (p < 0.001 and p = 0.001, respectively) and grade (p < 0.001 and p = 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test, p = 0.031). Moreover, in univariate Cox regression analysis, surgical margin (p = 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (p = 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS. Conclusions Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients. |
| first_indexed | 2024-12-11T00:23:58Z |
| format | Article |
| id | doaj.art-14e1c9ec99144d3e902e391b3b6a6444 |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-12-11T00:23:58Z |
| publishDate | 2020-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-14e1c9ec99144d3e902e391b3b6a64442022-12-22T01:27:38ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092020-09-013211810.1186/s43046-020-00047-zSignificance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinomaNabiha Missaoui0Ahlem Bdioui1Atika Baccouche2Oussema Belkacem3Wissem Hmida4Moncef Mokni5Sihem Hmissa6Faculty of Sciences and Techniques of Sidi Bouzid, Kairouan UniversityPathology Department, Farhet Hached University HospitalPathology Department, Sahloul University HospitalPathology Department, Sahloul University HospitalUrology Department, Sahloul University HospitalPathology Department, Farhet Hached University HospitalPathology Department, Sahloul University HospitalAbstract Background The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section. Results Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (p = 0.001), positive surgical margin (p = 0.005), and shorter recurrence-free survival (RFS; Log Rank test, p = 0.026). Ki-67 and p27 expression was associated with stage (p < 0.001 and p = 0.001, respectively) and grade (p < 0.001 and p = 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test, p = 0.031). Moreover, in univariate Cox regression analysis, surgical margin (p = 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (p = 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS. Conclusions Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.http://link.springer.com/article/10.1186/s43046-020-00047-zUpper urinary tract urothelial carcinomap53 expressionPositive surgical marginSurvival |
| spellingShingle | Nabiha Missaoui Ahlem Bdioui Atika Baccouche Oussema Belkacem Wissem Hmida Moncef Mokni Sihem Hmissa Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma Journal of the Egyptian National Cancer Institute Upper urinary tract urothelial carcinoma p53 expression Positive surgical margin Survival |
| title | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
| title_full | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
| title_fullStr | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
| title_full_unstemmed | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
| title_short | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
| title_sort | significance of p53 p27 ki 67 e cadherin and her2 expression in upper urinary tract urothelial carcinoma |
| topic | Upper urinary tract urothelial carcinoma p53 expression Positive surgical margin Survival |
| url | http://link.springer.com/article/10.1186/s43046-020-00047-z |
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