Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰
Background: The transmission of diseases by blood products continues to be a worldwide health problem, especially in Africa. Seroprevalence rates of the Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis, and Coinfection in Angola are poorly documented. Th...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867023009649 |
| _version_ | 1797391897683034112 |
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| author | Angelina Edna Quintas Cláudia Camila Dias Adis Del Carmen Cogle Lemuel Cordeiro António Sarmento |
| author_facet | Angelina Edna Quintas Cláudia Camila Dias Adis Del Carmen Cogle Lemuel Cordeiro António Sarmento |
| author_sort | Angelina Edna Quintas |
| collection | DOAJ |
| description | Background: The transmission of diseases by blood products continues to be a worldwide health problem, especially in Africa. Seroprevalence rates of the Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis, and Coinfection in Angola are poorly documented. This study aims to identify the seroprevalence of markers with positive results for Hepatitis B, C, HIV, Syphilis, and Coinfection in blood donors. Material and methods: A retrospective study was conducted using a database of positive serological markers for these infections and coinfection in 2734 blood donors traced from 2011 to 2016 in Luanda, Angola. The Chi-Square test (χ2) or Fisher's exact test was used to evaluate serological positivity and donors’ characteristics. A p-value < 0.05 was considered statistically significant. Results: 2734 blood donors aged 18 to 64 (median age 32 ± 9) were screened from 2011 to 2016. 73.9 % of the donors were positive for one Transfusion-Transmitted Infection (TTI), and 5.9 % showed evidence of multiple infections. The overall seroprevalence rate was 50.2 % (1373) for HBV, 20 % (436) for Syphilis, 7 % (191) for HIV, 5.1 % (140) for HCV, and 5.8 % for coinfected donors. 2467 (90 %) were men, and 267 (10 %) were women. We identified 118 (5.8 %) coinfected donors. Of those, 40 (33.9 %) simultaneously presented Hepatitis B virus surface antigen (HBsAg)/Syphilis, 24 (20.3 %) HBsAg/HIV, 22 (18.6 %) HBsAg/HCV, 20 (16.9 %) HIV/Syphilis, 8 (6.8 %) HCV/Syphilis, and 4 (3.4 %) HIV/HCV. Conclusion: A high transfusion-transmissible infection prevalence was found compared to some countries in Sub-Saharan Africa. Therefore, intensifying the screening for these transfusion-transmitted infections in blood donors is critical to ensure blood safety. |
| first_indexed | 2024-03-08T23:39:23Z |
| format | Article |
| id | doaj.art-14e2c60091db426e8151f6aafc6fd802 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-03-08T23:39:23Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-14e2c60091db426e8151f6aafc6fd8022023-12-14T05:20:50ZengElsevierBrazilian Journal of Infectious Diseases1413-86702023-11-01276103704Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰Angelina Edna Quintas0Cláudia Camila Dias1Adis Del Carmen Cogle2Lemuel Cordeiro3António Sarmento4Faculdade de Medicina da Universidade do Porto (FMUP), Departamento de Medicina Comunitária, Informação e Decisão em Saúde e Centro de Pesquisa em Tecnologias e Serviços de Saúde, Porto, Portugal; Faculdade de Medicina da Universidade do Porto (FMUP), Departamento de Medicina, Porto, Portugal; Clínica Girassol, Department of Education Office, Luanda, Angola; Corresponding author.Faculdade de Medicina da Universidade do Porto (FMUP), Departamento de Medicina Comunitária, Informação e Ciências da Decisão em Saúde (MEDCIDS) e Unidade de Gestão do Conhecimento, Porto, PortugalClínica Girassol in Luanda, Department of Hematology, Luanda, AngolaClínica Girassol, Department of Education Office, Luanda, AngolaCentro Hospitalar Universitário São João, Serviço de Doenças Infecciosas, Porto, Portugal; Faculdade de Medicina da Universidade do Porto (FMUP), Departamento de Medicina, Porto, PortugalBackground: The transmission of diseases by blood products continues to be a worldwide health problem, especially in Africa. Seroprevalence rates of the Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis, and Coinfection in Angola are poorly documented. This study aims to identify the seroprevalence of markers with positive results for Hepatitis B, C, HIV, Syphilis, and Coinfection in blood donors. Material and methods: A retrospective study was conducted using a database of positive serological markers for these infections and coinfection in 2734 blood donors traced from 2011 to 2016 in Luanda, Angola. The Chi-Square test (χ2) or Fisher's exact test was used to evaluate serological positivity and donors’ characteristics. A p-value < 0.05 was considered statistically significant. Results: 2734 blood donors aged 18 to 64 (median age 32 ± 9) were screened from 2011 to 2016. 73.9 % of the donors were positive for one Transfusion-Transmitted Infection (TTI), and 5.9 % showed evidence of multiple infections. The overall seroprevalence rate was 50.2 % (1373) for HBV, 20 % (436) for Syphilis, 7 % (191) for HIV, 5.1 % (140) for HCV, and 5.8 % for coinfected donors. 2467 (90 %) were men, and 267 (10 %) were women. We identified 118 (5.8 %) coinfected donors. Of those, 40 (33.9 %) simultaneously presented Hepatitis B virus surface antigen (HBsAg)/Syphilis, 24 (20.3 %) HBsAg/HIV, 22 (18.6 %) HBsAg/HCV, 20 (16.9 %) HIV/Syphilis, 8 (6.8 %) HCV/Syphilis, and 4 (3.4 %) HIV/HCV. Conclusion: A high transfusion-transmissible infection prevalence was found compared to some countries in Sub-Saharan Africa. Therefore, intensifying the screening for these transfusion-transmitted infections in blood donors is critical to ensure blood safety.http://www.sciencedirect.com/science/article/pii/S1413867023009649Transfusion-transmissible infectionSeroprevalenceBlood donorsÁfrica |
| spellingShingle | Angelina Edna Quintas Cláudia Camila Dias Adis Del Carmen Cogle Lemuel Cordeiro António Sarmento Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ Brazilian Journal of Infectious Diseases Transfusion-transmissible infection Seroprevalence Blood donors África |
| title | Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ |
| title_full | Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ |
| title_fullStr | Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ |
| title_full_unstemmed | Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ |
| title_short | Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola✰ |
| title_sort | seroprevalence of viral transfusion transmissible infections hbsag anti hcv anti hiv syphilis and coinfection among healthy volunteer blood donors during 5 years in luanda angola✰ |
| topic | Transfusion-transmissible infection Seroprevalence Blood donors África |
| url | http://www.sciencedirect.com/science/article/pii/S1413867023009649 |
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