A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification.
Designing targeted treatments for breast cancer patients after primary tumor removal is necessary to prevent the occurrence of invasive disease events (IDEs), such as recurrence, metastasis, contralateral and second tumors, over time. However, due to the molecular heterogeneity of this disease, pred...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274691 |
| _version_ | 1811243104913588224 |
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| author | Raffaella Massafra Maria Colomba Comes Samantha Bove Vittorio Didonna Sergio Diotaiuti Francesco Giotta Agnese Latorre Daniele La Forgia Annalisa Nardone Domenico Pomarico Cosmo Maurizio Ressa Alessandro Rizzo Pasquale Tamborra Alfredo Zito Vito Lorusso Annarita Fanizzi |
| author_facet | Raffaella Massafra Maria Colomba Comes Samantha Bove Vittorio Didonna Sergio Diotaiuti Francesco Giotta Agnese Latorre Daniele La Forgia Annalisa Nardone Domenico Pomarico Cosmo Maurizio Ressa Alessandro Rizzo Pasquale Tamborra Alfredo Zito Vito Lorusso Annarita Fanizzi |
| author_sort | Raffaella Massafra |
| collection | DOAJ |
| description | Designing targeted treatments for breast cancer patients after primary tumor removal is necessary to prevent the occurrence of invasive disease events (IDEs), such as recurrence, metastasis, contralateral and second tumors, over time. However, due to the molecular heterogeneity of this disease, predicting the outcome and efficacy of the adjuvant therapy is challenging. A novel ensemble machine learning classification approach was developed to address the task of producing prognostic predictions of the occurrence of breast cancer IDEs at both 5- and 10-years. The method is based on the concept of voting among multiple models to give a final prediction for each individual patient. Promising results were achieved on a cohort of 529 patients, whose data, related to primary breast cancer, were provided by Istituto Tumori "Giovanni Paolo II" in Bari, Italy. Our proposal greatly improves the performances returned by the baseline original model, i.e., without voting, finally reaching a median AUC value of 77.1% and 76.3% for the IDE prediction at 5-and 10-years, respectively. Finally, the proposed approach allows to promote more intelligible decisions and then a greater acceptability in clinical practice since it returns an explanation of the IDE prediction for each individual patient through the voting procedure. |
| first_indexed | 2024-04-12T14:01:42Z |
| format | Article |
| id | doaj.art-14e58baed5f64c49840857c48c967a33 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T14:01:42Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-14e58baed5f64c49840857c48c967a332022-12-22T03:30:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027469110.1371/journal.pone.0274691A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification.Raffaella MassafraMaria Colomba ComesSamantha BoveVittorio DidonnaSergio DiotaiutiFrancesco GiottaAgnese LatorreDaniele La ForgiaAnnalisa NardoneDomenico PomaricoCosmo Maurizio RessaAlessandro RizzoPasquale TamborraAlfredo ZitoVito LorussoAnnarita FanizziDesigning targeted treatments for breast cancer patients after primary tumor removal is necessary to prevent the occurrence of invasive disease events (IDEs), such as recurrence, metastasis, contralateral and second tumors, over time. However, due to the molecular heterogeneity of this disease, predicting the outcome and efficacy of the adjuvant therapy is challenging. A novel ensemble machine learning classification approach was developed to address the task of producing prognostic predictions of the occurrence of breast cancer IDEs at both 5- and 10-years. The method is based on the concept of voting among multiple models to give a final prediction for each individual patient. Promising results were achieved on a cohort of 529 patients, whose data, related to primary breast cancer, were provided by Istituto Tumori "Giovanni Paolo II" in Bari, Italy. Our proposal greatly improves the performances returned by the baseline original model, i.e., without voting, finally reaching a median AUC value of 77.1% and 76.3% for the IDE prediction at 5-and 10-years, respectively. Finally, the proposed approach allows to promote more intelligible decisions and then a greater acceptability in clinical practice since it returns an explanation of the IDE prediction for each individual patient through the voting procedure.https://doi.org/10.1371/journal.pone.0274691 |
| spellingShingle | Raffaella Massafra Maria Colomba Comes Samantha Bove Vittorio Didonna Sergio Diotaiuti Francesco Giotta Agnese Latorre Daniele La Forgia Annalisa Nardone Domenico Pomarico Cosmo Maurizio Ressa Alessandro Rizzo Pasquale Tamborra Alfredo Zito Vito Lorusso Annarita Fanizzi A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. PLoS ONE |
| title | A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. |
| title_full | A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. |
| title_fullStr | A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. |
| title_full_unstemmed | A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. |
| title_short | A machine learning ensemble approach for 5- and 10-year breast cancer invasive disease event classification. |
| title_sort | machine learning ensemble approach for 5 and 10 year breast cancer invasive disease event classification |
| url | https://doi.org/10.1371/journal.pone.0274691 |
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