Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2

Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2

Spinocerebellar ataxia type 2 (SCA2) is a rare autosomal, dominantly inherited disease, in which the affected individuals have a disease onset around their third life decade. The molecular mechanisms underlying SCA2 are not yet completely understood, for which we hypothesize that aging plays a role...

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Bibliographic Details
Main Authors: Inês T. Afonso, Patrícia Lima, André Conceição, Carlos A. Matos, Clévio Nóbrega
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
spinocerebellar ataxia type 2
aging
polyglutamine diseases
autophagy
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/23/19/11896

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