The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population
Zhongyu Li,1 Xiangmin Yuan,2 Xin Liu,2 Yuping Yang,2 Li Huang,2 Qiuhong Tan,2 Cuilin Li2 1Department of Blood Transfusion, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412007, People’s Republic of China; 2Department of Pharmacy, Zhuzhou Hospital Affil...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-influence-of-slc22a3-genetic-polymorphisms-on-susceptibility-to-ty-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797789404408840192 |
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| author | Li Z Yuan X Liu X Yang Y Huang L Tan Q Li C |
| author_facet | Li Z Yuan X Liu X Yang Y Huang L Tan Q Li C |
| author_sort | Li Z |
| collection | DOAJ |
| description | Zhongyu Li,1 Xiangmin Yuan,2 Xin Liu,2 Yuping Yang,2 Li Huang,2 Qiuhong Tan,2 Cuilin Li2 1Department of Blood Transfusion, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412007, People’s Republic of China; 2Department of Pharmacy, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412007, People’s Republic of ChinaCorrespondence: Cuilin Li, Email licuilincindy@163.comBackground: Solute carrier family 22 member 3 (SLC22A3) gene had been reported to be associated with the efficacy of metformin in type 2 diabetes mellitus (T2DM). However, few studies reported the relationship between SLC22A3 polymorphism and T2DM. The aim of this study was to investigate the association of SLC22A3 polymorphism and susceptibility to T2DM in Chinese population.Methods: We identified SLC22A3 rs555754, rs3123636, rs3088442 genotypes of 450 T2DM patients and 220 healthy controls from the Chinese population. The association between SNPs of SLC22A3 and susceptibility of T2DM was evaluated.Results: The clinical characteristics were significantly different between T2DM patients and healthy controls. The polymorphisms of SLC22A3 rs555754 and rs3123636 were obviously associated with the susceptibility of T2DM which was adjusted for age, sex and BMI, while rs3088442 did not. And there was haplotype association of SLC22A3 rs3088442-rs3123636 with T2DM susceptibility.Conclusion: SLC22A3 rs555754 and rs3123636 polymorphisms were associated with the susceptibility to T2DM in Chinese Han population. Large sample size studies would be required to verify this association.Keywords: type 2 diabetes mellitus, SLC22A3 gene, polymorphism, T2DM |
| first_indexed | 2024-03-13T01:50:09Z |
| format | Article |
| id | doaj.art-14e78ddaf3384ee784c73b5772ad5c4a |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-13T01:50:09Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-14e78ddaf3384ee784c73b5772ad5c4a2023-07-02T19:49:17ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-06-01Volume 161775178184495The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese PopulationLi ZYuan XLiu XYang YHuang LTan QLi CZhongyu Li,1 Xiangmin Yuan,2 Xin Liu,2 Yuping Yang,2 Li Huang,2 Qiuhong Tan,2 Cuilin Li2 1Department of Blood Transfusion, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412007, People’s Republic of China; 2Department of Pharmacy, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412007, People’s Republic of ChinaCorrespondence: Cuilin Li, Email licuilincindy@163.comBackground: Solute carrier family 22 member 3 (SLC22A3) gene had been reported to be associated with the efficacy of metformin in type 2 diabetes mellitus (T2DM). However, few studies reported the relationship between SLC22A3 polymorphism and T2DM. The aim of this study was to investigate the association of SLC22A3 polymorphism and susceptibility to T2DM in Chinese population.Methods: We identified SLC22A3 rs555754, rs3123636, rs3088442 genotypes of 450 T2DM patients and 220 healthy controls from the Chinese population. The association between SNPs of SLC22A3 and susceptibility of T2DM was evaluated.Results: The clinical characteristics were significantly different between T2DM patients and healthy controls. The polymorphisms of SLC22A3 rs555754 and rs3123636 were obviously associated with the susceptibility of T2DM which was adjusted for age, sex and BMI, while rs3088442 did not. And there was haplotype association of SLC22A3 rs3088442-rs3123636 with T2DM susceptibility.Conclusion: SLC22A3 rs555754 and rs3123636 polymorphisms were associated with the susceptibility to T2DM in Chinese Han population. Large sample size studies would be required to verify this association.Keywords: type 2 diabetes mellitus, SLC22A3 gene, polymorphism, T2DMhttps://www.dovepress.com/the-influence-of-slc22a3-genetic-polymorphisms-on-susceptibility-to-ty-peer-reviewed-fulltext-article-DMSOtype 2 diabetes mellitusslc22a3 genepolymorphismt2dm. |
| spellingShingle | Li Z Yuan X Liu X Yang Y Huang L Tan Q Li C The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population Diabetes, Metabolic Syndrome and Obesity type 2 diabetes mellitus slc22a3 gene polymorphism t2dm. |
| title | The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population |
| title_full | The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population |
| title_fullStr | The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population |
| title_full_unstemmed | The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population |
| title_short | The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population |
| title_sort | influence of slc22a3 genetic polymorphisms on susceptibility to type 2 diabetes mellitus in chinese population |
| topic | type 2 diabetes mellitus slc22a3 gene polymorphism t2dm. |
| url | https://www.dovepress.com/the-influence-of-slc22a3-genetic-polymorphisms-on-susceptibility-to-ty-peer-reviewed-fulltext-article-DMSO |
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