Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis
Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2017-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117708705 |
| _version_ | 1797283773286449152 |
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| author | Jonathan S. Wall PhD Stephen J. Kennel PhD Emily B. Martin PhD |
| author_facet | Jonathan S. Wall PhD Stephen J. Kennel PhD Emily B. Martin PhD |
| author_sort | Jonathan S. Wall PhD |
| collection | DOAJ |
| description | Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging. These data provide support for a phase 1 positron emission tomography/computed tomography imaging trial of this reagent, labeled with iodine-124, in patients with all forms of systemic amyloidosis. |
| first_indexed | 2024-03-07T17:36:42Z |
| format | Article |
| id | doaj.art-14ecb53894044f948c61b7b1618f51d9 |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T17:36:42Z |
| publishDate | 2017-08-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-14ecb53894044f948c61b7b1618f51d92024-03-02T16:42:57ZengSAGE PublicationsMolecular Imaging1536-01212017-08-011610.1177/153601211770870510.1177_1536012117708705Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging AmyloidosisJonathan S. Wall PhD0Stephen J. Kennel PhD1Emily B. Martin PhD2 Amyloidosis and Cancer Theranostics Program, University of Tennessee Medical Center, Knoxville, TN, USA Amyloidosis and Cancer Theranostics Program, University of Tennessee Medical Center, Knoxville, TN, USA Amyloidosis and Cancer Theranostics Program, University of Tennessee Medical Center, Knoxville, TN, USAAmyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging. These data provide support for a phase 1 positron emission tomography/computed tomography imaging trial of this reagent, labeled with iodine-124, in patients with all forms of systemic amyloidosis.https://doi.org/10.1177/1536012117708705 |
| spellingShingle | Jonathan S. Wall PhD Stephen J. Kennel PhD Emily B. Martin PhD Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis Molecular Imaging |
| title | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
| title_full | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
| title_fullStr | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
| title_full_unstemmed | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
| title_short | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
| title_sort | dual energy spect and the development of peptide p5 14 for imaging amyloidosis |
| url | https://doi.org/10.1177/1536012117708705 |
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