| Summary: | In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of <i>Rhodiola</i> spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from <i>R. semenovii</i> roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (<i>p</i> ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of <i>R. semenovii</i> extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.
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