Antihypothyroid Effect of Salidroside
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7487 |
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| author | Nazym K. Korbozova Nataliya O. Kudrina Nataliya A. Zhukova Alexander E. Grazhdannikov Irina V. Blavachinskaya Gulnaz A. Seitimova Timur E. Kulmanov Tatyana G. Tolstikova Nina V. Terletskaya |
| author_facet | Nazym K. Korbozova Nataliya O. Kudrina Nataliya A. Zhukova Alexander E. Grazhdannikov Irina V. Blavachinskaya Gulnaz A. Seitimova Timur E. Kulmanov Tatyana G. Tolstikova Nina V. Terletskaya |
| author_sort | Nazym K. Korbozova |
| collection | DOAJ |
| description | In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of <i>Rhodiola</i> spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from <i>R. semenovii</i> roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (<i>p</i> ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of <i>R. semenovii</i> extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times. |
| first_indexed | 2024-03-09T18:47:39Z |
| format | Article |
| id | doaj.art-14ef0f7ceaf34799a193c9fd02b44459 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:47:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-14ef0f7ceaf34799a193c9fd02b444592023-11-24T06:05:02ZengMDPI AGMolecules1420-30492022-11-012721748710.3390/molecules27217487Antihypothyroid Effect of SalidrosideNazym K. Korbozova0Nataliya O. Kudrina1Nataliya A. Zhukova2Alexander E. Grazhdannikov3Irina V. Blavachinskaya4Gulnaz A. Seitimova5Timur E. Kulmanov6Tatyana G. Tolstikova7Nina V. Terletskaya8Faculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Science, 630090 Novosibirsk, RussiaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Science, 630090 Novosibirsk, RussiaFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanInstitute of Genetic and Physiology, Al-Farabi Av., 93, Almaty 050040, KazakhstanN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Science, 630090 Novosibirsk, RussiaFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanIn terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of <i>Rhodiola</i> spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from <i>R. semenovii</i> roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (<i>p</i> ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of <i>R. semenovii</i> extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.https://www.mdpi.com/1420-3049/27/21/7487<i>Rhodiola semenovii</i> Boriss.salidrosidethyroidantihypothyroid effect |
| spellingShingle | Nazym K. Korbozova Nataliya O. Kudrina Nataliya A. Zhukova Alexander E. Grazhdannikov Irina V. Blavachinskaya Gulnaz A. Seitimova Timur E. Kulmanov Tatyana G. Tolstikova Nina V. Terletskaya Antihypothyroid Effect of Salidroside Molecules <i>Rhodiola semenovii</i> Boriss. salidroside thyroid antihypothyroid effect |
| title | Antihypothyroid Effect of Salidroside |
| title_full | Antihypothyroid Effect of Salidroside |
| title_fullStr | Antihypothyroid Effect of Salidroside |
| title_full_unstemmed | Antihypothyroid Effect of Salidroside |
| title_short | Antihypothyroid Effect of Salidroside |
| title_sort | antihypothyroid effect of salidroside |
| topic | <i>Rhodiola semenovii</i> Boriss. salidroside thyroid antihypothyroid effect |
| url | https://www.mdpi.com/1420-3049/27/21/7487 |
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