Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis
Abstract Background Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) drugs with ranibizumab and bevacizumab are current standard treatments. H...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0487-2 |
| _version_ | 1818875544891031552 |
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| author | Ya-li Zhou Chun-li Chen Yi-xiao Wang Yao Tong Xiao-ling Fang Lin Li Zhao-yang Wang |
| author_facet | Ya-li Zhou Chun-li Chen Yi-xiao Wang Yao Tong Xiao-ling Fang Lin Li Zhao-yang Wang |
| author_sort | Ya-li Zhou |
| collection | DOAJ |
| description | Abstract Background Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) drugs with ranibizumab and bevacizumab are current standard treatments. However, the outcome of anti-VEGF therapeutics is not uniform in all patients. Methods We performed a literature-based meta-analysis including, five published studies relevant to HTRA1 and response to anti-VEGF treatment (bevacizumab or ranibizumab). Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis and meta-regression were also performed. Q-statistic test and Egger’s test was used to evaluate heterogeneity and publication bias respectively. Results Overall, no association between the rs11200638 polymorphism in HTRA1 gene and the anti-VEGF treatment response was found in the genotype GG versus AA (OR = 1.06; 95% CI: 0.77 to 1.48; P = 0.98), genotype GA versus AA (OR = 1.11; 95% CI: 0.83 to 1.47; P = 0.93), genotype GG + GA versus AA (OR = 1.22; 95% CI: 0.94 to 1.57; P = 0.09), and allele G versus A (OR = 0.92; 95% CI: 0.78 to 1.08; P = 0.14). In the subgroup analysis by ethnicity Caucasian population, and a significant association was still not observed in all genetic models. Sensitivity analysis indicated the robustness of our findings, and no publication bias was observed in our meta-analysis. Conclusions This study shows that there was no association between the polymorphism rs11200638 in HTRA1 gene and response to anti-VEGF treatment of exudative AMD. However, more studies are needed to further prove the conclusion of present study, especially well-designed and high quality randomised controlled trials or intervention studies. |
| first_indexed | 2024-12-19T13:28:11Z |
| format | Article |
| id | doaj.art-14f00b6050b94c9ebde3aa0ac4a6e32e |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-19T13:28:11Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-14f00b6050b94c9ebde3aa0ac4a6e32e2022-12-21T20:19:29ZengBMCBMC Ophthalmology1471-24152017-06-011711910.1186/s12886-017-0487-2Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysisYa-li Zhou0Chun-li Chen1Yi-xiao Wang2Yao Tong3Xiao-ling Fang4Lin Li5Zhao-yang Wang6Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ophthalmology, Shengli Oilfield Central HospitalDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ophthalmology, Shanghai Eye HospitalDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineAbstract Background Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) drugs with ranibizumab and bevacizumab are current standard treatments. However, the outcome of anti-VEGF therapeutics is not uniform in all patients. Methods We performed a literature-based meta-analysis including, five published studies relevant to HTRA1 and response to anti-VEGF treatment (bevacizumab or ranibizumab). Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis and meta-regression were also performed. Q-statistic test and Egger’s test was used to evaluate heterogeneity and publication bias respectively. Results Overall, no association between the rs11200638 polymorphism in HTRA1 gene and the anti-VEGF treatment response was found in the genotype GG versus AA (OR = 1.06; 95% CI: 0.77 to 1.48; P = 0.98), genotype GA versus AA (OR = 1.11; 95% CI: 0.83 to 1.47; P = 0.93), genotype GG + GA versus AA (OR = 1.22; 95% CI: 0.94 to 1.57; P = 0.09), and allele G versus A (OR = 0.92; 95% CI: 0.78 to 1.08; P = 0.14). In the subgroup analysis by ethnicity Caucasian population, and a significant association was still not observed in all genetic models. Sensitivity analysis indicated the robustness of our findings, and no publication bias was observed in our meta-analysis. Conclusions This study shows that there was no association between the polymorphism rs11200638 in HTRA1 gene and response to anti-VEGF treatment of exudative AMD. However, more studies are needed to further prove the conclusion of present study, especially well-designed and high quality randomised controlled trials or intervention studies.http://link.springer.com/article/10.1186/s12886-017-0487-2Anti-VEGFExudative AMDHTRA1 geneTreatment response |
| spellingShingle | Ya-li Zhou Chun-li Chen Yi-xiao Wang Yao Tong Xiao-ling Fang Lin Li Zhao-yang Wang Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis BMC Ophthalmology Anti-VEGF Exudative AMD HTRA1 gene Treatment response |
| title | Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis |
| title_full | Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis |
| title_fullStr | Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis |
| title_full_unstemmed | Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis |
| title_short | Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis |
| title_sort | association between polymorphism rs11200638 in the htra1 gene and the response to anti vegf treatment of exudative amd a meta analysis |
| topic | Anti-VEGF Exudative AMD HTRA1 gene Treatment response |
| url | http://link.springer.com/article/10.1186/s12886-017-0487-2 |
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