Study progress of CCR3 in wet age-related macular degeneration
According to the study, chemokine receptor 3(CCR3)in the eye is mainly distributed in retinal pigment epithelial cells, and also expressed in the choroidal vascular endothelial cells(CECs). The specificity of CCR3's high expression in wet age-related macular degeneration(AMD)was found, and it i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-03-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://www.ies.net.cn/cn_publish/2014/3/201403020.pdf |
| _version_ | 1818272919003856896 |
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| author | Xian-Wei Wu Zhe-Li Liu |
| author_facet | Xian-Wei Wu Zhe-Li Liu |
| author_sort | Xian-Wei Wu |
| collection | DOAJ |
| description | According to the study, chemokine receptor 3(CCR3)in the eye is mainly distributed in retinal pigment epithelial cells, and also expressed in the choroidal vascular endothelial cells(CECs). The specificity of CCR3's high expression in wet age-related macular degeneration(AMD)was found, and it is proved that in wet-AMD patients, it plays an important role in the formation of choroidal neovascularization(CNV). In this paper, the structure, function, the problem of current research and the future direction of CCR3 were summarized. It is believed that with the further research on CCR3, it will not only help us to find a new method of wet-AMD diagnosis and treatment, but also may provide an important reference for other CNV disease research and new anti-CNV drugs. |
| first_indexed | 2024-12-12T21:49:43Z |
| format | Article |
| id | doaj.art-14f50ba49d434c0388175f7f1ba40689 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-12T21:49:43Z |
| publishDate | 2014-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-14f50ba49d434c0388175f7f1ba406892022-12-22T00:10:50ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232014-03-0114345745910.3980/j.issn.1672-5123.2014.03.20Study progress of CCR3 in wet age-related macular degenerationXian-Wei Wu0Zhe-Li Liu1Department of Ophthalmology, Benxi Central Hospital, Benxi 117000, Liaoning Province, ChinaDepartment of Ophthalmology, the First Hospital of China Medical University, Shenyang 110000, Liaoning Province, ChinaAccording to the study, chemokine receptor 3(CCR3)in the eye is mainly distributed in retinal pigment epithelial cells, and also expressed in the choroidal vascular endothelial cells(CECs). The specificity of CCR3's high expression in wet age-related macular degeneration(AMD)was found, and it is proved that in wet-AMD patients, it plays an important role in the formation of choroidal neovascularization(CNV). In this paper, the structure, function, the problem of current research and the future direction of CCR3 were summarized. It is believed that with the further research on CCR3, it will not only help us to find a new method of wet-AMD diagnosis and treatment, but also may provide an important reference for other CNV disease research and new anti-CNV drugs.http://www.ies.net.cn/cn_publish/2014/3/201403020.pdfwet age-related macular degenerationreceptorchemokine receptor 3chemokine receptor 3 |
| spellingShingle | Xian-Wei Wu Zhe-Li Liu Study progress of CCR3 in wet age-related macular degeneration Guoji Yanke Zazhi wet age-related macular degeneration receptor chemokine receptor 3 chemokine receptor 3 |
| title | Study progress of CCR3 in wet age-related macular degeneration |
| title_full | Study progress of CCR3 in wet age-related macular degeneration |
| title_fullStr | Study progress of CCR3 in wet age-related macular degeneration |
| title_full_unstemmed | Study progress of CCR3 in wet age-related macular degeneration |
| title_short | Study progress of CCR3 in wet age-related macular degeneration |
| title_sort | study progress of ccr3 in wet age related macular degeneration |
| topic | wet age-related macular degeneration receptor chemokine receptor 3 chemokine receptor 3 |
| url | http://www.ies.net.cn/cn_publish/2014/3/201403020.pdf |
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