Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature
Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload. Although uncommon, intrahepatic cholestasis may be severe and medical treatment of this complication is often ineffective. We report...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-05-01
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| Series: | Hematology Reports |
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| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/4371 |
| _version_ | 1797936013501267968 |
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| author | Morey Blinder B. Geng Mauricio Lisker-Melman Jeffrey S. Crippin Kevin Korenblat William Chapman Shalini Shenoy Joshua J. Field |
| author_facet | Morey Blinder B. Geng Mauricio Lisker-Melman Jeffrey S. Crippin Kevin Korenblat William Chapman Shalini Shenoy Joshua J. Field |
| author_sort | Morey Blinder |
| collection | DOAJ |
| description | Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload. Although uncommon, intrahepatic cholestasis may be severe and medical treatment of this complication is often ineffective. We report a case of a 37 year-old male patient with sickle cell anemia, who developed liver failure and underwent successful orthotopic liver transplantation. Both pre and post-operatively, he was maintained on red cell transfusions. He remains stable with improved liver function 42 months post transplant. The role for orthotopic liver transplantation is not well defined in patients with sickle cell disease, and the experience remains limited. Although considerable challenges of post-transplant graft complications remain, orthotopic liver transplantation should be considered as a treatment option for sickle cell disease patients with end-stage liver disease who have progressed despite conventional medical therapy. An extended period of red cell transfusion support may lessen the post-operative complications. |
| first_indexed | 2024-04-10T18:23:02Z |
| format | Article |
| id | doaj.art-14f5c32217d44b19b780fdb3919f3885 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:23:02Z |
| publishDate | 2013-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-14f5c32217d44b19b780fdb3919f38852023-02-02T06:32:35ZengMDPI AGHematology Reports2038-83222038-83302013-05-0151e1e110.4081/hr.2013.e12460Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literatureMorey Blinder0B. Geng1Mauricio Lisker-Melman2Jeffrey S. Crippin3Kevin Korenblat4William Chapman5Shalini Shenoy6Joshua J. Field7Department of Medicine, Department of Pathology, Washington University in St. LouisDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineMedical College of WisconsinSickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload. Although uncommon, intrahepatic cholestasis may be severe and medical treatment of this complication is often ineffective. We report a case of a 37 year-old male patient with sickle cell anemia, who developed liver failure and underwent successful orthotopic liver transplantation. Both pre and post-operatively, he was maintained on red cell transfusions. He remains stable with improved liver function 42 months post transplant. The role for orthotopic liver transplantation is not well defined in patients with sickle cell disease, and the experience remains limited. Although considerable challenges of post-transplant graft complications remain, orthotopic liver transplantation should be considered as a treatment option for sickle cell disease patients with end-stage liver disease who have progressed despite conventional medical therapy. An extended period of red cell transfusion support may lessen the post-operative complications.http://www.pagepress.org/journals/index.php/hr/article/view/4371Sickle cell diseasehepatopathytransfusions |
| spellingShingle | Morey Blinder B. Geng Mauricio Lisker-Melman Jeffrey S. Crippin Kevin Korenblat William Chapman Shalini Shenoy Joshua J. Field Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature Hematology Reports Sickle cell disease hepatopathy transfusions |
| title | Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| title_full | Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| title_fullStr | Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| title_full_unstemmed | Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| title_short | Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| title_sort | successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature |
| topic | Sickle cell disease hepatopathy transfusions |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/4371 |
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