Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives
In the present study, a series of new substituted 5-(1H-Indol-3-yl)-3-(phenyl)-4,5-dihydropyrazoline derivatives (2a–m) have been synthesized with good yield by microwave assisted synthesis. The compounds synthesized were screened for antidepressant and anticonvulsant potentialities in mice by a for...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535213003079 |
| _version_ | 1819094630574063616 |
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| author | Pravin O. Patil Sanjay B. Bari |
| author_facet | Pravin O. Patil Sanjay B. Bari |
| author_sort | Pravin O. Patil |
| collection | DOAJ |
| description | In the present study, a series of new substituted 5-(1H-Indol-3-yl)-3-(phenyl)-4,5-dihydropyrazoline derivatives (2a–m) have been synthesized with good yield by microwave assisted synthesis. The compounds synthesized were screened for antidepressant and anticonvulsant potentialities in mice by a forced swim test and subcutaneous pentylenetetrazole (scPTZ) test, respectively. Neuro-toxicities were determined by rotarod test in albino mice. The structures of all new compounds were confirmed by IR, 1H NMR, mass spectral data, and microanalyses. The results revealed that compounds 2b, 2e and 2k were found to be potent antidepressant molecules of the series, at 20 mg/kg dose level when compared with the reference drugs imipramine and fluoxetine. Whereas, compounds 2c and 2d were found to be potent anticonvulsant molecules of this series, when compared with the reference drug diazepam. None of the synthesized compounds showed neurotoxicity. |
| first_indexed | 2024-12-21T23:30:28Z |
| format | Article |
| id | doaj.art-14f70c284d7e42828124311798b77359 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-21T23:30:28Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-14f70c284d7e42828124311798b773592022-12-21T18:46:30ZengElsevierArabian Journal of Chemistry1878-53522016-07-019458859510.1016/j.arabjc.2013.08.027Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivativesPravin O. Patil0Sanjay B. Bari1Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur District, Dhule 425405, Maharashtra, IndiaDepartment of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur District, Dhule 425405, Maharashtra, IndiaIn the present study, a series of new substituted 5-(1H-Indol-3-yl)-3-(phenyl)-4,5-dihydropyrazoline derivatives (2a–m) have been synthesized with good yield by microwave assisted synthesis. The compounds synthesized were screened for antidepressant and anticonvulsant potentialities in mice by a forced swim test and subcutaneous pentylenetetrazole (scPTZ) test, respectively. Neuro-toxicities were determined by rotarod test in albino mice. The structures of all new compounds were confirmed by IR, 1H NMR, mass spectral data, and microanalyses. The results revealed that compounds 2b, 2e and 2k were found to be potent antidepressant molecules of the series, at 20 mg/kg dose level when compared with the reference drugs imipramine and fluoxetine. Whereas, compounds 2c and 2d were found to be potent anticonvulsant molecules of this series, when compared with the reference drug diazepam. None of the synthesized compounds showed neurotoxicity.http://www.sciencedirect.com/science/article/pii/S1878535213003079PyrazolineMicrowave assisted synthesisAnticonvulsantIndoleAntidepressant |
| spellingShingle | Pravin O. Patil Sanjay B. Bari Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives Arabian Journal of Chemistry Pyrazoline Microwave assisted synthesis Anticonvulsant Indole Antidepressant |
| title | Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives |
| title_full | Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives |
| title_fullStr | Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives |
| title_full_unstemmed | Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives |
| title_short | Synthesis, characterization and screening for antidepressant and anticonvulsant activity of 4,5-dihydropyrazole bearing indole derivatives |
| title_sort | synthesis characterization and screening for antidepressant and anticonvulsant activity of 4 5 dihydropyrazole bearing indole derivatives |
| topic | Pyrazoline Microwave assisted synthesis Anticonvulsant Indole Antidepressant |
| url | http://www.sciencedirect.com/science/article/pii/S1878535213003079 |
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