Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate
Abstract The aim was to evaluate the effects of chronic vitamin D (VD) supplementation associated with regular swimming over renal histomorphometric aspects in obese rats. Thirty Wistar male rats (5 days old) were used. Twenty four rats were given subcutaneous injections of monosodium glutamate (MSG...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2020-12-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700938&tlng=en |
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| author | KÉSIA ZANUZO ZOÉ M. GUARESCHI ANNA CAROLINY DETOGNI LUIZ PIERRE HUNING PATRICK F. RODRIGUES ELAINE M. PORTO SABRINA GRASSIOLLI JOÃO PAULO A. AMORIM |
| author_facet | KÉSIA ZANUZO ZOÉ M. GUARESCHI ANNA CAROLINY DETOGNI LUIZ PIERRE HUNING PATRICK F. RODRIGUES ELAINE M. PORTO SABRINA GRASSIOLLI JOÃO PAULO A. AMORIM |
| author_sort | KÉSIA ZANUZO |
| collection | DOAJ |
| description | Abstract The aim was to evaluate the effects of chronic vitamin D (VD) supplementation associated with regular swimming over renal histomorphometric aspects in obese rats. Thirty Wistar male rats (5 days old) were used. Twenty four rats were given subcutaneous injections of monosodium glutamate (MSG; 4 g/kg), and six control rats were given an equimolar saline solution. At 21-days-old, the MSG-treated rats were randomly distributed among sedentary animals (S) and exercised (E, swimming; 3x/week). These groups were subdivided into groups orally supplemented with VD (12 μg/kg; 3x/week) or not supplemented (NS), totaling Five experimental groups (n = 6 rats/group): MSG, MSG-SVD, MSG-ENS, MSG-EVD and control groups. In MSG-obese rats, there was such as a decrease in the diameter of the, glomerular tuft, Bowman’s capsule, Bowman’s space areas, and renal cortical thickness, compared to the control group. In MSG-SVD, MSG-ENS, and MSG-EVD animals, there was an increase in the cortical thickness in relation to the MSG group. In MSG-ENS and MSG-EVD animals, there was a reduction of tubular degeneration in relation to the MSG group. We conclude that physical exercise associated with Vitamin D supplementation can prevent of renal injury, increasing the thickness of the renal cortex and decrease the tubular degeneration. |
| first_indexed | 2024-12-24T01:41:03Z |
| format | Article |
| id | doaj.art-14f72ea090fe402fab7f819b75b14a1d |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-24T01:41:03Z |
| publishDate | 2020-12-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-14f72ea090fe402fab7f819b75b14a1d2022-12-21T17:22:00ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-12-0192410.1590/0001-3765202020201097Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamateKÉSIA ZANUZOhttps://orcid.org/0000-0002-6397-2160ZOÉ M. GUARESCHIhttps://orcid.org/0000-0002-3852-7073ANNA CAROLINY DETOGNIhttps://orcid.org/0000-0003-1003-0097LUIZ PIERRE HUNINGhttps://orcid.org/0000-0001-9158-9583PATRICK F. RODRIGUEShttps://orcid.org/0000-0002-7692-597XELAINE M. PORTOhttps://orcid.org/0000-0002-0538-2461SABRINA GRASSIOLLIhttps://orcid.org/0000-0001-5647-7877JOÃO PAULO A. AMORIMhttps://orcid.org/0000-0003-2245-548XAbstract The aim was to evaluate the effects of chronic vitamin D (VD) supplementation associated with regular swimming over renal histomorphometric aspects in obese rats. Thirty Wistar male rats (5 days old) were used. Twenty four rats were given subcutaneous injections of monosodium glutamate (MSG; 4 g/kg), and six control rats were given an equimolar saline solution. At 21-days-old, the MSG-treated rats were randomly distributed among sedentary animals (S) and exercised (E, swimming; 3x/week). These groups were subdivided into groups orally supplemented with VD (12 μg/kg; 3x/week) or not supplemented (NS), totaling Five experimental groups (n = 6 rats/group): MSG, MSG-SVD, MSG-ENS, MSG-EVD and control groups. In MSG-obese rats, there was such as a decrease in the diameter of the, glomerular tuft, Bowman’s capsule, Bowman’s space areas, and renal cortical thickness, compared to the control group. In MSG-SVD, MSG-ENS, and MSG-EVD animals, there was an increase in the cortical thickness in relation to the MSG group. In MSG-ENS and MSG-EVD animals, there was a reduction of tubular degeneration in relation to the MSG group. We conclude that physical exercise associated with Vitamin D supplementation can prevent of renal injury, increasing the thickness of the renal cortex and decrease the tubular degeneration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700938&tlng=enMonosodium glutamatehypothalamic obesityphysical exerciserenal tubular degenerationcholecalciferol |
| spellingShingle | KÉSIA ZANUZO ZOÉ M. GUARESCHI ANNA CAROLINY DETOGNI LUIZ PIERRE HUNING PATRICK F. RODRIGUES ELAINE M. PORTO SABRINA GRASSIOLLI JOÃO PAULO A. AMORIM Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate Anais da Academia Brasileira de Ciências Monosodium glutamate hypothalamic obesity physical exercise renal tubular degeneration cholecalciferol |
| title | Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate |
| title_full | Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate |
| title_fullStr | Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate |
| title_full_unstemmed | Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate |
| title_short | Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate |
| title_sort | physical exercise associated with vitamin d chronic supplementation reduces kidney injury induced by monosodium glutamate |
| topic | Monosodium glutamate hypothalamic obesity physical exercise renal tubular degeneration cholecalciferol |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700938&tlng=en |
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