Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives
<abstract language="eng">Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2003-05-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014 |
| _version_ | 1811319928607735808 |
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| author | Marcus Vinícius Nora de Souza Mauro Vieira de Almeida |
| author_facet | Marcus Vinícius Nora de Souza Mauro Vieira de Almeida |
| author_sort | Marcus Vinícius Nora de Souza |
| collection | DOAJ |
| description | <abstract language="eng">Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics. |
| first_indexed | 2024-04-13T12:50:52Z |
| format | Article |
| id | doaj.art-14f79b9e45ac446d8e9bc33defd0d0e5 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-04-13T12:50:52Z |
| publishDate | 2003-05-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-14f79b9e45ac446d8e9bc33defd0d0e52022-12-22T02:46:12ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642003-05-0126336637210.1590/S0100-40422003000300014Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectivesMarcus Vinícius Nora de SouzaMauro Vieira de Almeida<abstract language="eng">Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014AIDSnew Anti-HIV drugsreplicative cycle |
| spellingShingle | Marcus Vinícius Nora de Souza Mauro Vieira de Almeida Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives Química Nova AIDS new Anti-HIV drugs replicative cycle |
| title | Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives |
| title_full | Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives |
| title_fullStr | Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives |
| title_full_unstemmed | Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives |
| title_short | Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives |
| title_sort | drogas anti vih passado presente e perspectivas futuras drugs anti hiv past present and future perspectives |
| topic | AIDS new Anti-HIV drugs replicative cycle |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300014 |
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