Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses.

Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses.

The induction of a strong mucosal immune response is essential to building successful HIV vaccines. Highly attenuated recombinant HIV vaccinia virus can be administered mucosally, but even high doses of immunization have been found unable to induce strong mucosal antibody responses. In order to solv...

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Bibliographic Details
Main Authors: Yan Zhang, Jingyi Yang, Rong Bao, Yaoqing Chen, Dihan Zhou, Benxia He, Maohua Zhong, Yaoming Li, Fang Liu, Qiaoli Li, Yi Yang, Chen Han, Ying Sun, Yuan Cao, Huimin Yan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174162?pdf=render

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