RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days
The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either administered 4-MeI by oral gavage (0, 50, 100, 200, or...
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| Format: | Article |
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Elsevier
2021-10-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340921007022 |
| _version_ | 1829495938701328384 |
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| author | Michael B. Black Melvin E. Andersen Salil N. Pendse Susan J. Borghoff Michael Streicker Patrick D. McMullen |
| author_facet | Michael B. Black Melvin E. Andersen Salil N. Pendse Susan J. Borghoff Michael Streicker Patrick D. McMullen |
| author_sort | Michael B. Black |
| collection | DOAJ |
| description | The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either administered 4-MeI by oral gavage (0, 50, 100, 200, or 300 mg/kg/day) for 2 days or exposed for 5 and 28 days to 4-MeI in the diet (0, 150, 300, 1250, or 2500 ppm) and whole transcriptome (RNA-Sequencing) data from 4-MeI-exposed B6C3F1 mice to determine whether changes occurred in the target (lung) and nontarget (liver) tissues. This analysis was conducted to provide information with which to evaluate biological processes affected by exposure to 4-MeI, with a focus on identifying key events that could be used to propose a plausible mode of action (MoA) for mouse lung tumors [2]. |
| first_indexed | 2024-12-16T07:20:19Z |
| format | Article |
| id | doaj.art-14f8cca609cc494895eaded385e8c96a |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-16T07:20:19Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-14f8cca609cc494895eaded385e8c96a2022-12-21T22:39:39ZengElsevierData in Brief2352-34092021-10-0138107420RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 daysMichael B. Black0Melvin E. Andersen1Salil N. Pendse2Susan J. Borghoff3Michael Streicker4Patrick D. McMullen5ScitoVation LLC 100 Capitola Dr., Suite 106, Durham, NC 27713, USAScitoVation LLC 100 Capitola Dr., Suite 106, Durham, NC 27713, USAScitoVation LLC 100 Capitola Dr., Suite 106, Durham, NC 27713, USAToxStrategies Inc. 1249 Kildaire Farm Rd. #134, Cary, NC 27511, USA; Corresponding author.Integrated Laboratory Systems (ILS) 601 Keystone Park Drive, Suite 200 Morrisville, NC 27560, USAScitoVation LLC 100 Capitola Dr., Suite 106, Durham, NC 27713, USAThe National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either administered 4-MeI by oral gavage (0, 50, 100, 200, or 300 mg/kg/day) for 2 days or exposed for 5 and 28 days to 4-MeI in the diet (0, 150, 300, 1250, or 2500 ppm) and whole transcriptome (RNA-Sequencing) data from 4-MeI-exposed B6C3F1 mice to determine whether changes occurred in the target (lung) and nontarget (liver) tissues. This analysis was conducted to provide information with which to evaluate biological processes affected by exposure to 4-MeI, with a focus on identifying key events that could be used to propose a plausible mode of action (MoA) for mouse lung tumors [2].http://www.sciencedirect.com/science/article/pii/S23523409210070224-Methylimidazole4-MeIMouse lung and liverRNA-SeqDose response |
| spellingShingle | Michael B. Black Melvin E. Andersen Salil N. Pendse Susan J. Borghoff Michael Streicker Patrick D. McMullen RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days Data in Brief 4-Methylimidazole 4-MeI Mouse lung and liver RNA-Seq Dose response |
| title | RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days |
| title_full | RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days |
| title_fullStr | RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days |
| title_full_unstemmed | RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days |
| title_short | RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days |
| title_sort | rna sequencing transcriptomic data collected in liver and lung of male and female b6c3f1 mice exposed to various dose levels of 4 methylimidazole for 2 5 or 28 days |
| topic | 4-Methylimidazole 4-MeI Mouse lung and liver RNA-Seq Dose response |
| url | http://www.sciencedirect.com/science/article/pii/S2352340921007022 |
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