Anti-TNF Withdrawal in Inflammatory Bowel Disease
The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-05-01
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| Series: | GE: Portuguese Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2341454515001453 |
| _version_ | 1819142916972478464 |
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| author | Joana Torres Marília Cravo Jean-Frédéric Colombel |
| author_facet | Joana Torres Marília Cravo Jean-Frédéric Colombel |
| author_sort | Joana Torres |
| collection | DOAJ |
| description | The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF withdrawal has emerged as an important consideration in clinical practice. Herein our goal was to discuss the available evidence about anti-TNFα discontinuation in IBD that could inform the clinician on the expected rates of relapse, the potential predictors of relapse, as well the response to re-treatment. |
| first_indexed | 2024-12-22T12:17:57Z |
| format | Article |
| id | doaj.art-14f8e57578184b6bb2f0a51ce85346f3 |
| institution | Directory Open Access Journal |
| issn | 2341-4545 |
| language | English |
| last_indexed | 2024-12-22T12:17:57Z |
| publishDate | 2016-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | GE: Portuguese Journal of Gastroenterology |
| spelling | doaj.art-14f8e57578184b6bb2f0a51ce85346f32022-12-21T18:26:05ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452016-05-0123315316110.1016/j.jpge.2015.11.004Anti-TNF Withdrawal in Inflammatory Bowel DiseaseJoana Torres0Marília Cravo1Jean-Frédéric Colombel2Surgical Department, Gastroenterology Division, Hospital Beatriz Ângelo, Loures, PortugalSurgical Department, Gastroenterology Division, Hospital Beatriz Ângelo, Loures, PortugalThe Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USAThe introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF withdrawal has emerged as an important consideration in clinical practice. Herein our goal was to discuss the available evidence about anti-TNFα discontinuation in IBD that could inform the clinician on the expected rates of relapse, the potential predictors of relapse, as well the response to re-treatment.http://www.sciencedirect.com/science/article/pii/S2341454515001453Inflammatory Bowel Diseases/drug therapyTumor Necrosis Factor-Alpha/antagonists and inhibitorsTumor Necrosis Factor-Alpha/therapeutic useWithholding Treatment |
| spellingShingle | Joana Torres Marília Cravo Jean-Frédéric Colombel Anti-TNF Withdrawal in Inflammatory Bowel Disease GE: Portuguese Journal of Gastroenterology Inflammatory Bowel Diseases/drug therapy Tumor Necrosis Factor-Alpha/antagonists and inhibitors Tumor Necrosis Factor-Alpha/therapeutic use Withholding Treatment |
| title | Anti-TNF Withdrawal in Inflammatory Bowel Disease |
| title_full | Anti-TNF Withdrawal in Inflammatory Bowel Disease |
| title_fullStr | Anti-TNF Withdrawal in Inflammatory Bowel Disease |
| title_full_unstemmed | Anti-TNF Withdrawal in Inflammatory Bowel Disease |
| title_short | Anti-TNF Withdrawal in Inflammatory Bowel Disease |
| title_sort | anti tnf withdrawal in inflammatory bowel disease |
| topic | Inflammatory Bowel Diseases/drug therapy Tumor Necrosis Factor-Alpha/antagonists and inhibitors Tumor Necrosis Factor-Alpha/therapeutic use Withholding Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2341454515001453 |
| work_keys_str_mv | AT joanatorres antitnfwithdrawalininflammatoryboweldisease AT mariliacravo antitnfwithdrawalininflammatoryboweldisease AT jeanfredericcolombel antitnfwithdrawalininflammatoryboweldisease |