Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor
Musculoskeletal dysfunctions are highly prevalent due to increasing life expectancy. Consequently, novel solutions to optimize treatment of patients are required. The current major research focus is to develop innovative concepts for single tissues. However, interest is also emerging to generate app...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5177 |
| _version_ | 1797561702886146048 |
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| author | Nina Friese Mattis Benno Gierschner Patrik Schadzek Yvonne Roger Andrea Hoffmann |
| author_facet | Nina Friese Mattis Benno Gierschner Patrik Schadzek Yvonne Roger Andrea Hoffmann |
| author_sort | Nina Friese |
| collection | DOAJ |
| description | Musculoskeletal dysfunctions are highly prevalent due to increasing life expectancy. Consequently, novel solutions to optimize treatment of patients are required. The current major research focus is to develop innovative concepts for single tissues. However, interest is also emerging to generate applications for tissue transitions where highly divergent properties need to work together, as in bone-cartilage or bone-tendon transitions. Finding medical solutions for dysfunctions of such tissue transitions presents an added challenge, both in research and in clinics. This review aims to provide an overview of the anatomical structure of healthy adult entheses and their development during embryogenesis. Subsequently, important scientific progress in restoration of damaged entheses is presented. With respect to enthesis dysfunction, the review further focuses on inflammation. Although molecular, cellular and tissue mechanisms during inflammation are well understood, tissue regeneration in context of inflammation still presents an unmet clinical need and goes along with unresolved biological questions. Furthermore, this review gives particular attention to the potential role of a signaling mediator protein, transforming growth factor beta-activated kinase-1 (TAK1), which is at the node of regenerative and inflammatory signaling and is one example for a less regarded aspect and potential important link between tissue regeneration and inflammation. |
| first_indexed | 2024-03-10T18:18:32Z |
| format | Article |
| id | doaj.art-14fb490aa54746539f9f463f4c1ee129 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:18:32Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-14fb490aa54746539f9f463f4c1ee1292023-11-20T07:30:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115517710.3390/ijms21155177Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node FactorNina Friese0Mattis Benno Gierschner1Patrik Schadzek2Yvonne Roger3Andrea Hoffmann4Department of Orthopedic Surgery, Graded Implants and Regenerative Strategies, OE 8893, Laboratory for Biomechanics and Biomaterials, Hannover Medical School (MHH), 30625 Hannover, GermanyDepartment of Orthopedic Surgery, Graded Implants and Regenerative Strategies, OE 8893, Laboratory for Biomechanics and Biomaterials, Hannover Medical School (MHH), 30625 Hannover, GermanyDepartment of Orthopedic Surgery, Graded Implants and Regenerative Strategies, OE 8893, Laboratory for Biomechanics and Biomaterials, Hannover Medical School (MHH), 30625 Hannover, GermanyDepartment of Orthopedic Surgery, Graded Implants and Regenerative Strategies, OE 8893, Laboratory for Biomechanics and Biomaterials, Hannover Medical School (MHH), 30625 Hannover, GermanyDepartment of Orthopedic Surgery, Graded Implants and Regenerative Strategies, OE 8893, Laboratory for Biomechanics and Biomaterials, Hannover Medical School (MHH), 30625 Hannover, GermanyMusculoskeletal dysfunctions are highly prevalent due to increasing life expectancy. Consequently, novel solutions to optimize treatment of patients are required. The current major research focus is to develop innovative concepts for single tissues. However, interest is also emerging to generate applications for tissue transitions where highly divergent properties need to work together, as in bone-cartilage or bone-tendon transitions. Finding medical solutions for dysfunctions of such tissue transitions presents an added challenge, both in research and in clinics. This review aims to provide an overview of the anatomical structure of healthy adult entheses and their development during embryogenesis. Subsequently, important scientific progress in restoration of damaged entheses is presented. With respect to enthesis dysfunction, the review further focuses on inflammation. Although molecular, cellular and tissue mechanisms during inflammation are well understood, tissue regeneration in context of inflammation still presents an unmet clinical need and goes along with unresolved biological questions. Furthermore, this review gives particular attention to the potential role of a signaling mediator protein, transforming growth factor beta-activated kinase-1 (TAK1), which is at the node of regenerative and inflammatory signaling and is one example for a less regarded aspect and potential important link between tissue regeneration and inflammation.https://www.mdpi.com/1422-0067/21/15/5177enthesis organembryonic developmentadultregenerationinflammationimmune system |
| spellingShingle | Nina Friese Mattis Benno Gierschner Patrik Schadzek Yvonne Roger Andrea Hoffmann Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor International Journal of Molecular Sciences enthesis organ embryonic development adult regeneration inflammation immune system |
| title | Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor |
| title_full | Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor |
| title_fullStr | Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor |
| title_full_unstemmed | Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor |
| title_short | Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor |
| title_sort | regeneration of damaged tendon bone junctions entheses tak1 as a potential node factor |
| topic | enthesis organ embryonic development adult regeneration inflammation immune system |
| url | https://www.mdpi.com/1422-0067/21/15/5177 |
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