Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in m...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01403-9 |
| _version_ | 1818977930502471680 |
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| author | Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac |
| author_facet | Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac |
| author_sort | Teresa Pérez-Berezo |
| collection | DOAJ |
| description | Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice. |
| first_indexed | 2024-12-20T16:35:34Z |
| format | Article |
| id | doaj.art-14fbaec632884e6fbafc02bc5cea62fa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:35:34Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-14fbaec632884e6fbafc02bc5cea62fa2022-12-21T19:33:09ZengNature PortfolioNature Communications2041-17232017-11-018111210.1038/s41467-017-01403-9Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917Teresa Pérez-Berezo0Julien Pujo1Patricia Martin2Pauline Le Faouder3Jean-Marie Galano4Alexandre Guy5Claude Knauf6Jean Claude Tabet7Sophie Tronnet8Frederick Barreau9Maud Heuillet10Gilles Dietrich11Justine Bertrand-Michel12Thierry Durand13Eric Oswald14Nicolas Cenac15IRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierMetaToulLipidomics Facility, INSERM UMR1048Institut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMInstitut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierSorbonne Université, UPMC Univ Paris 06, CNRS, Institut Parisien de Chimie Moléculaire (IPCM)IRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierLISBP, Université de Toulouse, CNRS, INRA, INSAIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierMetaToulLipidomics Facility, INSERM UMR1048Institut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierEscherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.https://doi.org/10.1038/s41467-017-01403-9 |
| spellingShingle | Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 Nature Communications |
| title | Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 |
| title_full | Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 |
| title_fullStr | Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 |
| title_full_unstemmed | Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 |
| title_short | Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 |
| title_sort | identification of an analgesic lipopeptide produced by the probiotic escherichia coli strain nissle 1917 |
| url | https://doi.org/10.1038/s41467-017-01403-9 |
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