Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene
A recent discovery of the unique biological properties of two-dimensional transition metal carbides (MXenes) resulted in intensive research on their application in various biotechnological areas, including polymeric nanocomposite systems. However, the true potential of MXene as an additive to bioact...
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MDPI AG
2020-10-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/20/4587 |
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| author | Anita Rozmysłowska-Wojciechowska Ewa Karwowska Michał Gloc Jarosław Woźniak Mateusz Petrus Bartłomiej Przybyszewski Tomasz Wojciechowski Agnieszka M. Jastrzębska |
| author_facet | Anita Rozmysłowska-Wojciechowska Ewa Karwowska Michał Gloc Jarosław Woźniak Mateusz Petrus Bartłomiej Przybyszewski Tomasz Wojciechowski Agnieszka M. Jastrzębska |
| author_sort | Anita Rozmysłowska-Wojciechowska |
| collection | DOAJ |
| description | A recent discovery of the unique biological properties of two-dimensional transition metal carbides (MXenes) resulted in intensive research on their application in various biotechnological areas, including polymeric nanocomposite systems. However, the true potential of MXene as an additive to bioactive natural porous composite structures has yet to be fully explored. Here, we report that the addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene by reducing the porosity of the chitosan-hyaluronate matrix nanocomposite structures, stabilized by vitamin C, maintains their desired antibacterial properties. This was confirmed by micro computed tomography (micro-CT) visualization which enables insight into the porous structure of nanocomposites. It was also found that given large porosity of the nanocomposite a small amount of MXene (1–5 wt.%) was effective against gram-negative <i>Escherichia coli,</i> gram-positive <i>Staphylococcus aureus,</i> and <i>Bacillus</i> sp. bacteria in a hydrogel system. Such an approach unequivocally advances the future design approaches of modern wound healing dressing materials with the addition of MXenes. |
| first_indexed | 2024-03-10T15:36:06Z |
| format | Article |
| id | doaj.art-14fc83e20be24cef8fad129a31b82d53 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T15:36:06Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-14fc83e20be24cef8fad129a31b82d532023-11-20T17:11:42ZengMDPI AGMaterials1996-19442020-10-011320458710.3390/ma13204587Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXeneAnita Rozmysłowska-Wojciechowska0Ewa Karwowska1Michał Gloc2Jarosław Woźniak3Mateusz Petrus4Bartłomiej Przybyszewski5Tomasz Wojciechowski6Agnieszka M. Jastrzębska7Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandFaculty of Building Services, Hydro and Environmental Engineering, Warsaw University of Technology, Nowowiejska 20, 00-653 Warsaw, PolandFaculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandFaculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandFaculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandFaculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, PolandA recent discovery of the unique biological properties of two-dimensional transition metal carbides (MXenes) resulted in intensive research on their application in various biotechnological areas, including polymeric nanocomposite systems. However, the true potential of MXene as an additive to bioactive natural porous composite structures has yet to be fully explored. Here, we report that the addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene by reducing the porosity of the chitosan-hyaluronate matrix nanocomposite structures, stabilized by vitamin C, maintains their desired antibacterial properties. This was confirmed by micro computed tomography (micro-CT) visualization which enables insight into the porous structure of nanocomposites. It was also found that given large porosity of the nanocomposite a small amount of MXene (1–5 wt.%) was effective against gram-negative <i>Escherichia coli,</i> gram-positive <i>Staphylococcus aureus,</i> and <i>Bacillus</i> sp. bacteria in a hydrogel system. Such an approach unequivocally advances the future design approaches of modern wound healing dressing materials with the addition of MXenes.https://www.mdpi.com/1996-1944/13/20/4587MXeneschitosanhyaluronatenanocomposite hydrogelantibacterialporosity |
| spellingShingle | Anita Rozmysłowska-Wojciechowska Ewa Karwowska Michał Gloc Jarosław Woźniak Mateusz Petrus Bartłomiej Przybyszewski Tomasz Wojciechowski Agnieszka M. Jastrzębska Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene Materials MXenes chitosan hyaluronate nanocomposite hydrogel antibacterial porosity |
| title | Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene |
| title_full | Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene |
| title_fullStr | Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene |
| title_full_unstemmed | Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene |
| title_short | Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene |
| title_sort | controlling the porosity and biocidal properties of the chitosan hyaluronate matrix hydrogel nanocomposites by the addition of 2d ti sub 3 sub c sub 2 sub t sub x sub mxene |
| topic | MXenes chitosan hyaluronate nanocomposite hydrogel antibacterial porosity |
| url | https://www.mdpi.com/1996-1944/13/20/4587 |
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